Ben Yosef R, Glaser B, Catane R
Dept. of Oncology, Hadassah Medical Center, Jerusalem.
Harefuah. 1990 Jul;119(1-2):15-8.
Somatostatin is a short-acting natural peptide secreted by specialized cells in the GI tract, the central and peripheral nervous systems, and a variety of other tissues. Its many actions include suppression of the secretion of GH, TSH, GI hormones, and inhibition of GI exocrine secretion. A long-acting analogue developed by Sandoz (Sandostatin, SMS 201-995) has been used to treat acromegaly and neuroendocrine tumors. We report our experience with it in carcinoid tumors (4 cases), glucagonomas (2), gastrinoma (1), VIPoma (1) and nonfunctioning islet cell tumor (1). It was given by continuous subcutaneous infusion, using a small portable pump, in doses ranging from 300 to 1500 mcg/day, without significant side-effects. 7 of the 9 patients had complete relief of symptoms, and tumoral hormone secretion decreased in 4 of the 5 in whom it was measurable, but there was no evidence of tumor regression. SMS 201-995 is useful for the symptomatic treatment of patients with neuroendocrine gut tumors.
生长抑素是一种短效天然肽，由胃肠道、中枢和外周神经系统以及多种其他组织中的特化细胞分泌。它的多种作用包括抑制生长激素、促甲状腺激素、胃肠激素的分泌，以及抑制胃肠外分泌。山德士公司研发的一种长效类似物（善宁，SMS 201-995）已被用于治疗肢端肥大症和神经内分泌肿瘤。我们报告了其在类癌肿瘤（4例）、胰高血糖素瘤（2例）、胃泌素瘤（1例）、血管活性肠肽瘤（1例）和无功能性胰岛细胞瘤（1例）中的应用经验。使用小型便携式泵通过皮下持续输注给药，剂量为每天300至1500微克，无明显副作用。9例患者中有7例症状完全缓解，5例可测量肿瘤激素分泌的患者中有4例肿瘤激素分泌减少，但没有肿瘤缩小的证据。SMS 201-995对神经内分泌肠道肿瘤患者的症状性治疗有用。
