He Dan, Wang Menglei, Zhao Siyu, Shu Yisong, Zeng Honglian, Xiao Cheng, Lu Cheng, Liu Yuanyan
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
Fitoterapia. 2017 Jun;119:136-149. doi: 10.1016/j.fitote.2017.05.001. Epub 2017 May 8.
Quinazolinones belong to a family of heterocyclic nitrogen compounds that have attracted increasing interest because of their broad spectrum of biological functions. This review describes three types of natural quinazolinones and their synthesized derivatives and summarizes their various pharmacological activities, including antifungal, anti-tumor, anti-malaria, anticonvulsant, anti-microbial, anti-inflammatory and antihyperlipidemic activities. In addition, structure-activity relationships of quinazolinone derivatives are also reviewed.
喹唑啉酮属于一类杂环氮化合物，由于其广泛的生物学功能而越来越受到关注。这篇综述描述了三种类型的天然喹唑啉酮及其合成衍生物，并总结了它们的各种药理活性，包括抗真菌、抗肿瘤、抗疟疾、抗惊厥、抗微生物、抗炎和抗高血脂活性。此外，还综述了喹唑啉酮衍生物的构效关系。
