Jannot Anne-Sophie, Zapletal Eric, Avillach Paul, Mamzer Marie-France, Burgun Anita, Degoulet Patrice
Paris Descartes Faculty of Medicine, Paris, France; INSERM UMR 1138-E22: Information Sciences to Support Personalized Medicine, Paris, France; Medical Informatics, Biostatistics and Public Health Department, Georges Pompidou University Hospital, Paris, France.
Medical Informatics, Biostatistics and Public Health Department, Georges Pompidou University Hospital, Paris, France.
Int J Med Inform. 2017 Jun;102:21-28. doi: 10.1016/j.ijmedinf.2017.02.006. Epub 2017 Feb 16.
When developed jointly with clinical information systems, clinical data warehouses (CDWs) facilitate the reuse of healthcare data and leverage clinical research.
To describe both data access and use for clinical research, epidemiology and health service research of the "Hôpital Européen Georges Pompidou" (HEGP) CDW.
The CDW has been developed since 2008 using an i2b2 platform. It was made available to health professionals and researchers in October 2010. Procedures to access data have been implemented and different access levels have been distinguished according to the nature of queries.
As of July 2016, the CDW contained the consolidated data of over 860,000 patients followed since the opening of the HEGP hospital in July 2000. These data correspond to more than 122 million clinical item values, 124 million biological item values, and 3.7 million free text reports. The ethics committee of the hospital evaluates all CDW projects that generate secondary data marts. Characteristics of the 74 research projects validated between January 2011 and December 2015 are described.
The use of HEGP CDWs is a key facilitator for clinical research studies. It required however important methodological and organizational support efforts from a biomedical informatics department.
临床数据仓库（CDW）与临床信息系统联合开发时，有助于医疗数据的重复利用并推动临床研究。
描述“欧洲乔治·蓬皮杜医院”（HEGP）临床数据仓库在临床研究、流行病学和卫生服务研究方面的数据访问和使用情况。
该临床数据仓库自2008年起使用i2b2平台进行开发。2010年10月向卫生专业人员和研究人员开放。已实施数据访问程序，并根据查询性质区分了不同的访问级别。
截至2016年7月，临床数据仓库包含了自2000年7月HEGP医院开业以来跟踪的86万多名患者的整合数据。这些数据对应超过1.22亿条临床项目值、1.24亿条生物项目值和370万份自由文本报告。医院伦理委员会评估所有生成二级数据集市的临床数据仓库项目。描述了2011年1月至2015年12月期间通过验证的74个研究项目的特点。
使用HEGP临床数据仓库是临床研究的关键推动因素。然而，这需要生物医学信息学部门在方法和组织方面做出重要的支持努力。
