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唾液酸酶在感染中的作用:鼠伤寒沙门氏菌LT2血清型唾液酸酶基因敲除菌株的基因组释放

Implication of Sialidases in Infection: Genome Release of Sialidase Knockout Strains from Serovar Typhimurium LT2.

作者信息

Arabyan Narine, Weis Allison M, Huang Bihua C, Weimer Bart C

机构信息

Department of Population Health and Reproduction, School of Veterinary Medicine, UC Davis, Davis, California, USA.

100K Pathogen Genome Project, UC Davis, Davis, California, USA.

出版信息

Genome Announc. 2017 May 11;5(19):e00341-17. doi: 10.1128/genomeA.00341-17.

Abstract

Sialidases, which are widely distributed in nature, cleave the α-ketosidic bond of terminal sialic acid residue. These emerging virulence factors degrade the host glycan. We report here the release of seven sialidase and one sialic acid transporter deletion in serovar Typhimurium strain LT2, which are important in cellular invasion during infection.

摘要

唾液酸酶广泛存在于自然界,可切割末端唾液酸残基的α-酮糖苷键。这些新出现的毒力因子会降解宿主聚糖。我们在此报告在鼠伤寒血清型菌株LT2中缺失了七种唾液酸酶和一种唾液酸转运蛋白,这些在感染期间的细胞侵袭中很重要。

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