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具有新兴毒力因子几丁质酶缺失的鼠伤寒沙门氏菌LT2菌株的基因组序列草图

Draft Genome Sequences of Serovar Typhimurium LT2 with Deleted Chitinases That Are Emerging Virulence Factors.

作者信息

Arabyan Narine, Huang Bihua C, Weimer Bart C

机构信息

Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California, USA.

100K Pathogen Genome Project, University of California, Davis, California, USA.

出版信息

Genome Announc. 2017 Aug 3;5(31):e00659-17. doi: 10.1128/genomeA.00659-17.

DOI:10.1128/genomeA.00659-17
PMID:28774970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5543632/
Abstract

Chitinases are glycosyl hydrolases that catalyze the hydrolysis of the β-1,4 linkages in complex carbohydrates and those that contain GlcNAc. These enzymes are considered emerging virulence factors during infection because the host glycan changes. This is the release of four single chitinase deletion mutants in serovar Typhimurium LT2.

摘要

几丁质酶是糖基水解酶,可催化复杂碳水化合物以及含有N-乙酰葡糖胺的碳水化合物中β-1,4键的水解。这些酶被认为是感染期间新出现的毒力因子,因为宿主聚糖会发生变化。这是鼠伤寒血清型LT2中四个单几丁质酶缺失突变体的释放。

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本文引用的文献

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Genome Announc. 2017 May 11;5(19):e00341-17. doi: 10.1128/genomeA.00341-17.
2
Large-Scale Release of Campylobacter Draft Genomes: Resources for Food Safety and Public Health from the 100K Pathogen Genome Project.弯曲杆菌基因组草图的大规模发布:来自10万病原体基因组计划的食品安全与公共卫生资源
Genome Announc. 2017 Jan 5;5(1):e00925-16. doi: 10.1128/genomeA.00925-16.
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Genome Announc. 2016 Dec 1;4(6):e01324-16. doi: 10.1128/genomeA.01324-16.
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Mol Cell Proteomics. 2016 Dec;15(12):3653-3664. doi: 10.1074/mcp.M116.063206. Epub 2016 Oct 17.
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Salmonella Degrades the Host Glycocalyx Leading to Altered Infection and Glycan Remodeling.沙门氏菌降解宿主糖萼,导致感染改变和聚糖重塑。
Sci Rep. 2016 Jul 8;6:29525. doi: 10.1038/srep29525.
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