Department of Prevention, Cancer Research UK, London, UK.
Department of Public Health Modelling, UK Health Forum, London, UK.
Tob Control. 2018 Mar;27(2):129-135. doi: 10.1136/tobaccocontrol-2016-053507. Epub 2017 May 11.
Smoking is still the most preventable cause of cancer, and a leading cause of premature mortality and health inequalities in the UK. This study modelled the health and economic impacts of achieving a 'tobacco-free' ambition (TFA) where, by 2035, less than 5% of the population smoke tobacco across all socioeconomic groups.
A non-linear multivariate regression model was fitted to cross-sectional smoking data to create projections to 2035. These projections were used to predict the future incidence and costs of 17 smoking-related diseases using a microsimulation approach. The health and economic impacts of achieving a TFA were evaluated against a predicted baseline scenario, where current smoking trends continue.
If trends continue, the prevalence of smoking in the UK was projected to be 10% by 2035-well above a TFA. If this ambition were achieved by 2035, it could mean 97 300 +/- 5 300 new cases of smoking-related diseases are avoided by 2035 (tobacco-related cancers: 35 900+/- 4 100; chronic obstructive pulmonary disease: 29 000 +/- 2 700; stroke: 24 900 +/- 2 700; coronary heart disease: 7600 +/- 2 700), including around 12 350 diseases avoided in 2035 alone. The consequence of this health improvement is predicted to avoid £67 +/- 8 million in direct National Health Service and social care costs, and £548 million in non-health costs, in 2035 alone.
These findings strengthen the case to set bold targets on long-term declines in smoking prevalence to achieve a tobacco 'endgame'. Results demonstrate the health and economic benefits that meeting a TFA can achieve over just 20 years. Effective ambitions and policy interventions are needed to reduce the disease and economic burden of smoking.
吸烟仍然是癌症最可预防的原因,也是英国过早死亡和健康不平等的主要原因。本研究通过建模来模拟实现“无烟”目标(TFA)的健康和经济影响,即在 2035 年之前,所有社会经济群体中吸烟人口比例低于 5%。
使用非线性多变量回归模型对横断面吸烟数据进行拟合,以进行预测至 2035 年的预测。使用微观模拟方法,这些预测用于预测 17 种与吸烟相关的疾病的未来发病率和成本。通过与预测的基线情景进行比较,评估实现 TFA 的健康和经济影响,在基线情景中,当前的吸烟趋势持续下去。
如果趋势继续下去,预计到 2035 年,英国的吸烟率将达到 10%,远高于 TFA。如果到 2035 年实现这一目标,到 2035 年,可能避免 97300 例(97300 +/- 5300 例)与吸烟相关的疾病,其中包括 2035 年单独避免的 12350 例疾病(与烟草相关的癌症:35900 +/- 4100 例;慢性阻塞性肺疾病:29000 +/- 2700 例;中风:24900 +/- 2700 例;冠心病:7600 +/- 2700 例);仅在 2035 年,直接国家卫生服务和社会保健费用就可避免 6700 万英镑(67 +/- 800 万英镑),非健康费用可避免 5.48 亿英镑。
这些发现加强了设定长期降低吸烟率的大胆目标以实现烟草“终局”的理由。结果表明,实现 TFA 可以在短短 20 年内实现健康和经济效益。需要有效的目标和政策干预措施来减少吸烟造成的疾病和经济负担。