Gawroński Krzysztof, Rzepecki Piotr, Sawicki Waldemar, Wajs Jarosław
Department of Hematology and Bone Marrow Transplantation Unit, Military Medical Institute, Warsaw, Poland.
Department of Hematology and Bone Marrow Transplantation Unit, Military Institute of Medicine, Warsaw, Poland.
Ann Transplant. 2017 May 12;22:296-302. doi: 10.12659/aot.901875.
BACKGROUND To increase the number of circulating hematopoietic stem cells (HSC) in the blood, mobilization treatments are currently being used. G-CSF and G-CSF plus chemotherapy are the most common methods of hematopoietic stem cells separation used in Poland. MATERIAL AND METHODS We observed patients who failed an effective hematopoietic stem cell mobilization with G-CSF or with G-CSF plus chemotherapy. The separation was considered unsuccessful if within a period of 4 consecutive days of separation, the number of obtained CD 34+ cells was lower than 2.0×10^6/kg of bodyweight. The study involved 32 patients whose CD34+ cells were collected and the collection for autologous transplantation failed. The study included 20 men and 12 women. Among all 32 patients, 28 had multiple myeloma, 3 had DLBCL lymphoma, and 1 had Hodgkin's disease. RESULTS Separation was unsuccessful in only 3 patients; the remaining 29 achieved an average of 4.83×10^6 CD34+ cells per kg of bodyweight. We conclude that plerixafor is an important tool in obtaining sufficient quantities of cells for hematopoietic stem cells separation. CONCLUSIONS The use of plerixafor is a sufficient and safe option for stem cells mobilization in autologous transplantations.
背景 为增加血液中循环造血干细胞（HSC）的数量，目前正在采用动员治疗。粒细胞集落刺激因子（G-CSF）以及G-CSF加化疗是波兰最常用的造血干细胞分离方法。材料与方法 我们观察了那些使用G-CSF或G-CSF加化疗进行有效造血干细胞动员但失败的患者。如果在连续4天的分离期内，获得的CD 34+细胞数量低于2.0×10^6/kg体重，则认为分离不成功。该研究纳入了32例进行了CD34+细胞采集但自体移植采集失败的患者。研究包括20名男性和12名女性。在所有32例患者中，28例患有多发性骨髓瘤，3例患有弥漫性大B细胞淋巴瘤（DLBCL），1例患有霍奇金病。结果 仅3例患者分离不成功；其余29例患者每千克体重平均获得4.83×10^6个CD34+细胞。我们得出结论，普乐沙福是获取足够数量细胞用于造血干细胞分离的重要工具。结论 对于自体移植中的干细胞动员，使用普乐沙福是一种充分且安全的选择。
