Taizhou Hospital of Zhejiang Province, Linhai, 317000, China.
Lishui Municipal Central Hospital & the Fifth Affiliated Hospital, Wenzhou Medical University, Lishui, 323000, China.
Sci Rep. 2017 May 11;7(1):1739. doi: 10.1038/s41598-017-01579-6.
Although many common variants have been identified for bone mineral density (BMD) and osteoporosis fractures, all the identified risk variants could only explain a small portion of heritability of BMD and osteoporosis fractures. OPG belongs to the tumor necrosis factor receptor superfamily, which plays a crucial role in bone remodeling and is thus a promising candidate gene of osteoporosis. Several studies have explored the association of OPG variants with BMD or osteoporosis fractures, however, the results remain inconsistent among different populations. In the study, we first assessed the relationship between OPG variants and BMD or osteoporosis fractures in our sample size (227 subjects with postmenopausal osteoporosis and 189 controls), and then performed a systematic meta-analysis. Among the nine SNPs genotyped, rs6469804 and rs2073618 showed significant associations with both BMD and osteoporotic fractures, while rs3102735 was only associated with BMD in our samples (P < 0.05). For meta-analyses, data for a total of 12 SNPs were pooled (4725 patients and 37804 controls), and five SNPs, including rs6993813, rs6469804, rs3134070, rs2073618 and rs3102734, showed association with osteoporosis fractures (P < 0.05). On light of the above analysis, we believe that OPG is one promising susceptibility gene of BMD or osteoporotic fractures.
虽然已经确定了许多与骨密度（BMD）和骨质疏松性骨折相关的常见变体，但所有已确定的风险变体只能解释 BMD 和骨质疏松性骨折遗传率的一小部分。OPG 属于肿瘤坏死因子受体超家族，在骨重塑中起着至关重要的作用，因此是骨质疏松症的一个有前途的候选基因。已有多项研究探讨了 OPG 变体与 BMD 或骨质疏松性骨折之间的关系，但不同人群的结果仍不一致。在本研究中，我们首先评估了 OPG 变体与我们的样本量（227 名绝经后骨质疏松症患者和 189 名对照）中的 BMD 或骨质疏松性骨折之间的关系，然后进行了系统的荟萃分析。在 9 个基因分型的 SNP 中，rs6469804 和 rs2073618 与 BMD 和骨质疏松性骨折均有显著相关性，而 rs3102735 仅与我们样本中的 BMD 相关（P<0.05）。对于荟萃分析，共汇总了 12 个 SNP 的数据（4725 名患者和 37804 名对照），其中包括 rs6993813、rs6469804、rs3134070、rs2073618 和 rs3102734 在内的 5 个 SNP 与骨质疏松性骨折相关（P<0.05）。根据上述分析，我们认为 OPG 是一个有前途的 BMD 或骨质疏松性骨折易感基因。
