Gober Claire M, Carroll Patrick J, Joullié Madeleine M
Department of Chemistry, University of Pennsylvania, Philadelphia, PA, United States of America.
Mini Rev Org Chem. 2016;13(2):126-142. doi: 10.2174/1570193X13666160225001001.
Natural products bearing a triazaspirocyclic motif have received significant attention in recent years. These compounds, which feature three nitrogen atoms attached to one quaternary carbon forming a spirocyclic scaffold, exhibit a wide range of biological activity and have promising applications in materials as well as in drug discovery. In this review article, we will discuss triazaspirocycles in Nature, their biological activity, and applications. Methods for the synthesis of triazaspirocycles as well as the reactivity of triazaspirocyclic scaffolds will be reviewed.
近年来，带有三氮杂螺环基序的天然产物受到了广泛关注。这些化合物具有三个与一个季碳相连的氮原子，形成了一个螺环骨架，展现出广泛的生物活性，在材料以及药物发现方面具有广阔的应用前景。在这篇综述文章中，我们将讨论自然界中的三氮杂螺环化合物、它们的生物活性以及应用。还将综述三氮杂螺环化合物的合成方法以及三氮杂螺环骨架的反应活性。
