Hajheidari Samira, Miladi-Gorji Hossein, Bigdeli Imanollah
Faculty of Psychology and Educational Sciences, University of Semnan, Semnan, Iran.
Laboratory of Animal Addiction Models, Research Center and Department of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Iran J Psychiatry. 2017 Jan;12(1):8-14.
This study was designed to examine the effect of environmental enrichment during methamphetamine (METH) dependency and withdrawal on methamphetamine-induced spatial learning and memory deficits and obsessive-compulsive behavior. Adult male Wistar rats (200 ± 10 g) chronically received bi-daily doses of METH (2 mg/kg, sc, with 12 hours intervals) for 14 days. Rats reared in standard (SE) or enriched environment (EE) during the development of dependence on METH and withdrawal. Then, they were tested for spatial learning and memory (the water maze), and obsessive-compulsive behavior as grooming behavior in METH-withdrawn rats. The results revealed that the Sal/EE and METH/EE rats reared in EE spent more time in the target zone on the water maze and displayed significantly increased proximity to the platform compared to their control groups. METH withdrawn rats reared in EE displayed less grooming behavior than METH/SE group. : Our findings revealed EE ameliorates METH-induced spatial memory deficits and obsessive-compulsive behavior in rats.
本研究旨在探讨甲基苯丙胺（METH）依赖和戒断期间环境富集对METH诱导的空间学习记忆缺陷和强迫行为的影响。成年雄性Wistar大鼠（200±10 g）连续14天每天两次接受METH（2 mg/kg，皮下注射，间隔12小时）。大鼠在对METH产生依赖和戒断的过程中饲养于标准环境（SE）或富集环境（EE）中。然后，对它们进行空间学习记忆测试（水迷宫），并对戒断METH的大鼠的强迫行为（如梳理行为）进行测试。结果显示，与各自的对照组相比，饲养于EE中的Sal/EE和METH/EE大鼠在水迷宫目标区域花费的时间更多，并且与平台的接近程度显著增加。饲养于EE中的戒断METH大鼠的梳理行为比METH/SE组少。我们的研究结果表明，EE可改善大鼠中METH诱导的空间记忆缺陷和强迫行为。
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