Cha Myung-Jin, Oh Seil
Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
J Atr Fibrillation. 2013 Feb 12;5(5):676. doi: 10.4022/jafib.676. eCollection 2013 Feb-Mar.
Pericardial adiposity is strongly associated with increased cardiovascular risk, especially for coronary artery disease. However, until 2010 researchers have not focused on the mechanistic role of pericardial fat in atrial fibrillation (AF) pathogenesis. Only a limited number of studies have reported on the significant association between pericardial fat and AF prevalence, and the role of pericardial fat on AF chronicity and symptom burden remain an ongoing debate. Several possible mechanisms associating pericardial fat with increased AF prevalence have been suggested, but no prior studies have definitively elucidated the precise role of pericardial adiposity on increased AF risk. Currently, pericardial fat has recently emerged as a new independent AF risk factor. In this brief review, we discuss several potential mechanisms that might associate pericardial fat to AF pathogenesis.
心包脂肪过多与心血管风险增加密切相关，尤其是冠状动脉疾病。然而，直到2010年，研究人员才开始关注心包脂肪在心房颤动（AF）发病机制中的作用。仅有少数研究报道了心包脂肪与房颤患病率之间的显著关联，而心包脂肪对房颤慢性化和症状负担的作用仍存在争议。已经提出了几种可能的心包脂肪与房颤患病率增加相关的机制，但之前没有研究明确阐明心包脂肪过多对房颤风险增加的确切作用。目前，心包脂肪最近已成为一个新的独立房颤风险因素。在这篇简短的综述中，我们讨论了几种可能将心包脂肪与房颤发病机制联系起来的潜在机制。
