Mohanty Sanghamitra, Di Biase Luigi, Mohanty Prasant, Santangeli Pasquale, Rong Bai, Chintan Trivedy, Burkhardt David, Gallinghouse Joseph G, Horton Rodney, Sanchez Javier E, Bailey Shane, Zagrodzky Jason, Natale Andrea
St. David?s Medical Center, Texas Cardiac Arrhythmia Institute, Austin, Texas.
School of Biological Sciences, University of Texas at Austin, Texas.
J Atr Fibrillation. 2013 Feb 12;5(5):798. doi: 10.4022/jafib.798. eCollection 2013 Feb-Mar.
Metabolic syndrome (MS), a pro-inflammatory state with hypertension, diabetes, dyslipidemia and obesity is presumed to be a close associate of atrial fibrillation (AF). However, the exact mechanism by which MS facilitates perpetuation of AF is yet to be fully understood. Moreover, the impact of the components of MS as well as MS as a group, on ablation-outcome in AF is not clearly elucidated until now. This review has compiled the results from major studies that have looked into those risk factors and defined their significance in influencing ablation-outcome in AF. It has also overviewed the impact of life-style changes that might improve the success rate of AF-ablation by effectively addressing the different constituents of MS.
代谢综合征(MS)是一种伴有高血压、糖尿病、血脂异常和肥胖的促炎状态,被认为与心房颤动(AF)密切相关。然而,MS促进AF持续存在的确切机制尚未完全明确。此外,MS各组分以及作为一个整体的MS对AF消融结果的影响至今仍未得到清晰阐明。本综述汇总了主要研究的结果,这些研究探讨了上述危险因素,并明确了它们在影响AF消融结果方面的意义。它还概述了生活方式改变可能产生的影响,即通过有效应对MS的不同组成部分来提高AF消融的成功率。