Kato T, Teshima S, Watanabe S, Yamada T, Tanemura K, Tsunematsu R, Ohmi K, Sonoda T, Kasamatsu T, Kishi K
Department of Gynecology, National Cancer Center Hospital, Tokyo.
Jpn J Clin Oncol. 1988 Dec;18(4):303-8.
An increasing trend in Japan of Müllerian mixed tumor (MMT) of the endometrium has been suspected from both the Annual Pathological Autopsy Records in Japan (APARJ) and an analysis of surgical cases from the National Cancer Center Hospital (NCCH). One hundred and four MMT cases were recorded in APARJ during the period, 1965-1984, which constituted 1.1% of all malignant uterine tumors. The number of MMT cases in the past 10 years (87 cases during the period, 1975-1984) increased more than fivefold over that of the previous 10 years (17 cases during the period, 1965-1974). The proportion among malignant uterine tumors also increased from 0.5 to 1.5%. Eighteen patients with MMT underwent surgery in the NCCH during the period, 1963-1986, which accounted for 4.3% of endometrial malignant tumor cases. Of these only one was resected during the 12-year period, 1963-1974, while there were 17 surgically resected cases during the 12 years from 1975 to 1986. These represented 0.8 and 5.7%, respectively of malignant tumors of the endometrium during the two periods. In five out of 18 cases, MMT occurred as a second primary malignancy, and in all cases the histology was one of mesodermal mixed tumor. It was suggested that its occurrence as a second primary malignancy would be contributing to the recent increase of MMT in Japan.
从日本年度病理尸检记录（APARJ）以及国立癌症中心医院（NCCH）的手术病例分析中，均怀疑日本子宫内膜米勒管混合瘤（MMT）呈上升趋势。1965年至1984年期间，APARJ记录了104例MMT病例，占所有子宫恶性肿瘤的1.1%。过去10年（1975年至1984年期间87例）的MMT病例数比前10年（1965年至1974年期间17例）增加了五倍多。在子宫恶性肿瘤中的比例也从0.5%增至1.5%。1963年至1986年期间，18例MMT患者在NCCH接受了手术，占子宫内膜恶性肿瘤病例的4.3%。其中，1963年至1974年这12年间仅1例接受了切除手术，而1975年至1986年这12年间有17例手术切除病例。这分别占两个时期子宫内膜恶性肿瘤的0.8%和5.7%。18例中有5例MMT作为第二原发性恶性肿瘤出现，所有病例的组织学类型均为中胚层混合瘤。有人认为，其作为第二原发性恶性肿瘤的出现是导致近期日本MMT增加的原因之一。
