Tsunematsu Y, Koide R, Kobayashi N
Cancer Registry Group, National Children's Hospital, Tokyo.
Jpn J Clin Oncol. 1988 Dec;18(4):309-20.
Developments in the treatment of childhood cancer have been evaluated in patients who had been treated in the National Children's Hospital from 1965 to 1987. The total number of patients was 867, of which leukemia accounted for 376, malignant lymphoma 61, neuroblastoma 174, Wilms' tumor 55, yolk sac tumor 29, rhabdomyosarcoma 36 and hepatoblastoma 30. Patients were divided into three time intervals: the 1960s, 1970s and 1980s. A marked improvement in five-year survival was recognized in Wilms' tumor and yolk sac tumor, amounting to 80%, followed by rhabdomyosarcoma, acute lymphoblastic leukemia and malignant lymphoma. There was no improvement in patients with acute non-lymphoblastic leukemia, neuroblastoma and hepatoblastoma. Prognostic factors for neuroblastoma were further analyzed, and the age of onset and stage of disease were found to have remained constant for 23 years. Factors relating to the improvement of survival were discussed.
对1965年至1987年在国家儿童医院接受治疗的儿童癌症患者的治疗进展进行了评估。患者总数为867人，其中白血病376人，恶性淋巴瘤61人，神经母细胞瘤174人，肾母细胞瘤55人，卵黄囊瘤29人，横纹肌肉瘤36人，肝母细胞瘤30人。患者被分为三个时间段：20世纪60年代、70年代和80年代。肾母细胞瘤和卵黄囊瘤的五年生存率有显著提高，达到80%，其次是横纹肌肉瘤、急性淋巴细胞白血病和恶性淋巴瘤。急性非淋巴细胞白血病、神经母细胞瘤和肝母细胞瘤患者的生存率没有提高。对神经母细胞瘤的预后因素进行了进一步分析，发现发病年龄和疾病分期在23年中保持不变。讨论了与生存率提高相关的因素。
