Kazemnejad Somaieh, Khanmohammadi Manijeh, Baheiraei Nafiseh, Arasteh Shaghayegh
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Department of Anatomical Sciences, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Avicenna J Med Biotechnol. 2017 Apr-Jun;9(2):50-65.
Cartilage is an avascular, aneural, and alymphatic connective tissue with a limited capacity caused by low mitotic activity of its resident cells, chondrocytes. Natural repair of full thickness cartilage defects usually leads to the formation of fibrocartilage with lower function and mechanical force compared with the original hyaline cartilage and further deterioration can occur. Tissue engineering and regenerative medicine is a promising strategy to repair bone and articular cartilage defects and rehabilitate joint functions by focusing on the optimal combination of cells, material scaffolds, and signaling molecules. The unique physical and topographical properties of nanofibrous structures allow them to mimic the extracellular matrix of native cartilage, making an appropriate resemblance to induce cartilage tissue regeneration and reconstruction. To improve simulation of native cartilage, the incorporation of nanofibrous scaffolds with suitable corresponsive cells could be effective. In this review article, an attempt was made to present the current state of cartilage tissue engineering using nanofibrous scaffolds and stem cells as high proliferative immune privilege cells with chondrogenic differentiation ability. The comprehensive information was retrieved by search of relevant subject headings in Medline/Pubmed and Elsevier databases.
软骨是一种无血管、无神经和无淋巴管的结缔组织，由于其驻留细胞软骨细胞的低有丝分裂活性，其修复能力有限。全层软骨缺损的自然修复通常会导致形成功能和机械力比原始透明软骨更低的纤维软骨，并且可能会进一步恶化。组织工程和再生医学是一种很有前景的策略，通过关注细胞、材料支架和信号分子的最佳组合来修复骨和关节软骨缺损并恢复关节功能。纳米纤维结构独特的物理和拓扑特性使其能够模拟天然软骨的细胞外基质，从而产生适当的相似性以诱导软骨组织再生和重建。为了更好地模拟天然软骨，将纳米纤维支架与合适的相应细胞结合可能会有效果。在这篇综述文章中，我们试图介绍使用纳米纤维支架和干细胞作为具有软骨分化能力的高增殖免疫特权细胞的软骨组织工程的现状。通过在Medline/Pubmed和爱思唯尔数据库中搜索相关主题词检索到了全面的信息。
