Saddadi Fereshteh, Rasoolzadeh Aida, Ganji Mohammadreza, Miri Maryam
Hasheminejad Kidney center Nephrology Ward, Iran University of Medical Sciences, Tehran, Iran.
University of Medical Sciences, Shiraz, Iran.
J Renal Inj Prev. 2016 Sep 3;6(2):99-102. doi: 10.15171/jrip.2017.19. eCollection 2017.
The level of fibroblast growth factor 23 (FGF23) may be considered as a prognostic factor for assessing renal function in regulating components of phosphate and vitamin D hemostasis. The present study aimed to evaluate the prognostic value of FGF23 level to predict renal function after renal transplantation. Fifteen consecutive patients scheduled for renal transplantation. To assess renal function status, the MDRD formula and isotope scan were applied. The study endpoint was to assess the level of FGF23 and other factors involving calcium and phosphorus metabolism before and also 3 and 12 months after transplantation and also to determine role of FGF23 to predict postoperative renal function. The mean level of FGF23 was 839.51±694.56 ρg/mL at baseline that reduced to 44.31±22.01 ρg/mL and 20.13±36.50 ρg/mL, 3 and 12 months after initial assessment. The levels of FGF23 was significantly lower at 3 and 12 months after baseline (=0.01 and =0.02, respectively) with no difference in FGF23 level between the time points of 3 and 12 months after transplantation. Baseline level of FGF23 was found to be higher in the patients with higher glomerular filtration rate (GFR), in older patients, in males, in those patients with diabetic nephropathy, in those with acceptable renal function than in patients who suffered transplant rejection. The level of postoperative FGF23 is an important marker for secretion of phosphorus from kidneys emphasizing the central role of FGF23 marker to regulate calcium and phosphorus metabolism after a successful renal transplantation.
成纤维细胞生长因子23（FGF23）水平可被视为评估肾功能的一个预后因素，其在调节磷酸盐和维生素D稳态成分方面发挥作用。本研究旨在评估FGF23水平对预测肾移植后肾功能的预后价值。连续纳入15例计划接受肾移植的患者。应用MDRD公式和同位素扫描评估肾功能状态。研究终点是评估移植前、移植后3个月和12个月时FGF23水平以及其他涉及钙磷代谢的因素，并确定FGF23预测术后肾功能的作用。基线时FGF23的平均水平为839.51±694.56 pg/mL，在初次评估后3个月和12个月时分别降至44.31±22.01 pg/mL和20.13±36.50 pg/mL。基线后3个月和12个月时FGF23水平显著降低（分别为P=0.01和P=0.02），移植后3个月和12个月时间点之间FGF23水平无差异。发现肾小球滤过率（GFR）较高的患者、老年患者、男性患者、患有糖尿病肾病的患者、肾功能可接受的患者的FGF23基线水平高于发生移植排斥反应的患者。术后FGF23水平是肾脏磷分泌的一个重要标志物，强调了FGF23标志物在成功肾移植后调节钙磷代谢中的核心作用。
