Conway R, Cournane S, Byrne D, O'Riordan D, Silke B
Department of Internal Medicine, St. James's Hospital, Dublin, 8, Ireland.
Medical Physics and Bioengineering Department, St. James's Hospital, Dublin, 8, Ireland.
Ir J Med Sci. 2018 Feb;187(1):5-11. doi: 10.1007/s11845-017-1627-7. Epub 2017 May 11.
Multiple studies have suggested an association between weekend hospital admissions and mortality. These have been limited by potential residual confounders and a lack of explanation of causation.
We previously attributed adverse weekend outcomes to higher acuity; we have re-examined this question for all emergency medical admissions to our institution from 2002 to 2014.
We divided admissions by a weekday or weekend (Friday to Sunday) hospital arrival. We utilised a multivariate logistic regression model, to determine whether the latter was independently predictive of 30-day in-hospital mortality.
There were 82,368 admissions in 44,628 patients over the 13-year period. Of admissions, 37.4% occurred at the weekend. The Acute Illness Severity Score, the Charlson Co-morbidity Index and the Chronic Disabling Disease Score were similar by a weekday or weekend admission. The multivariable logistic regression showed no increase in 30-day in-hospital mortality for weekend admissions, odds ratio 1.07 (95% confidence interval 0.98 to 1.16) (p = 0.11). Since the inception of the AMAU, the per patient mortality for a weekend admission has declined from 13.5% in 2002 to 4.4% in 2014. This represents a relative risk reduction of 67.9% with a number needed to treat of 10.8. Outcomes improved similarly for weekday and weekend admissions.
No increase in 30-day in-hospital mortality for weekend admissions was found in this study. There has been a substantial reduction in mortality for both weekday and weekend admissions over time.
多项研究表明周末住院与死亡率之间存在关联。这些研究受到潜在残留混杂因素的限制,且缺乏因果关系的解释。
我们之前将周末不良结局归因于更高的病情严重程度;我们重新审视了2002年至2014年期间我院所有急诊入院患者的这一问题。
我们根据患者入院时间是工作日还是周末(周五至周日)对入院情况进行划分。我们使用多变量逻辑回归模型来确定周末入院是否独立预测30天院内死亡率。
在这13年期间,44,628名患者中有82,368次入院。其中37.4%的入院发生在周末。急性疾病严重程度评分、查尔森合并症指数和慢性残疾疾病评分在工作日或周末入院时相似。多变量逻辑回归显示周末入院的30天院内死亡率没有增加,比值比为1.07(95%置信区间为0.98至1.16)(p = 0.11)。自急性医学评估单元(AMAU)成立以来,周末入院患者的人均死亡率从2002年的13.5%下降到2014年的4.4%。这代表相对风险降低了67.9%,需治疗人数为10.8。工作日和周末入院患者的结局改善情况相似。
本研究未发现周末入院的30天院内死亡率增加。随着时间的推移,工作日和周末入院患者的死亡率均大幅下降。