Clinic for Diagnostic and Interventional Radiology, Saarland University Hospital, Homburg, Germany.
Department of Internal Medicine V-Pulmonology, Allergology, and Respiratory Critical Care Medicine, Saarland University Hospital, Homburg, Germany.
Magn Reson Med. 2018 Feb;79(2):1052-1060. doi: 10.1002/mrm.26741. Epub 2017 May 11.
To investigate the potential of 3D ultrashort echo time MRI and short T images generated by subtraction for determination of total tumor burden in lung cancer.
As an animal model of spontaneously developing non-small cell lung cancer, the K-rasLA1 transgenic mouse was used. Three-dimensional MR imaging was performed with radial k-space acquisition and echo times of 20 µs and 1 ms. For investigation of the short T component in the recorded signal, subtraction images were generated from these data sets and used for consensus identification of tumors. Next, manual segmentation was performed on all MR images by two independent investigators. MRI data were compared with the results from histologic investigations and among the investigators.
Tumor number and total tumor burden from imaging experiments correlated strongly with the results of histologic investigations. Intra- and interuser comparison showed highest correlations between the individual measurements for ultra-short TE MRI.
Three-dimensional MRI protocols facilitate accurate tumor identification in mice harboring lung tumors. Ultrashort TE MRI is the superior imaging strategy when investigating lung tumors of miscellaneous size with 3D MR imaging strategies. Magn Reson Med 79:1052-1060, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
研究三维超短回波时间 MRI 和减影短 T 图像在肺癌总肿瘤负担测定中的应用潜力。
以自发性非小细胞肺癌 K-rasLA1 转基因小鼠为动物模型。采用径向 k 空间采集和 20μs 和 1ms 的回波时间进行三维 MR 成像。为了研究记录信号中的短 T 成分，从这些数据集生成减影图像，并用于肿瘤的共识识别。然后，由两名独立的研究者对所有 MR 图像进行手动分割。将 MRI 数据与组织学研究结果以及研究者之间进行比较。
成像实验中的肿瘤数量和总肿瘤负担与组织学研究结果高度相关。在个体测量之间，超短 TE MRI 的内部和用户间比较显示出最高的相关性。
三维 MRI 方案有助于在携带肺癌的小鼠中准确识别肿瘤。当使用三维 MRI 方案研究各种大小的肺癌时，超短 TE MRI 是优越的成像策略。磁共振医学 79:1052-1060, 2018。© 2017 国际磁共振学会。
