Kim Yoon Seob, Han Kyungdo, Lee Ji Hyun, Kim Nack In, Roh Joo Young, Seo Seong Jun, Song Hae Jun, Lee Min Geol, Choi Jee Ho, Park Young Min
Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Medical Statistics, The Catholic University of Korea College of Medicine, Seoul, Korea.
Allergy Asthma Immunol Res. 2017 Jul;9(4):373-377. doi: 10.4168/aair.2017.9.4.373.
There was no previous population-based study on the comparison of the risk of chronic spontaneous urticaria (CSU) between autoimmune thyroid diseases (AITD) and age- and gender-matched controls. The primary objective of this study was to evaluate the risk of CSU after diagnosis of AITD using national registry data from Korea. The secondary objective was to evaluate other risk factors of CSU. Based on the disease code diagnoses in 2003-2005, we composed an AITD group (n=3,659) and an age- and gender-matched control group (n=18,295). Each patient was tracked for whether CSU occurs or not until 2013. After adjusting for demographic differences and comorbidities, patients with AITD had a significantly higher rate of CSU compared to the control group (hazard ratio [HR], 1.46; 95% confidence interval [CI], 1.25-1.70; P<0.001). Among the AITD patients, the adjusted HR for CSU was higher in patients with Hashimoto's thyroiditis (HR, 1.50) than in those with Grave's disease (HR, 1.33), although the difference was not statistically significant (P=0.368). Analysis of CSU patients associated with AITD showed that female patients had a significantly higher risk of CSU compared to male ones (HR, 1.34; P=0.001) and that those with allergic rhinitis (HR, 1.51; P<0.001), atopic dermatitis (HR, 2.44; P<0.001), and asthma (HR, 1.50; P<0.001) had a significantly higher risk of CSU compared to patients without respective diseases. Our results demonstrated that AITD could be significantly associated with an increased risk of CSU.
此前尚无基于人群的研究比较自身免疫性甲状腺疾病（AITD）与年龄及性别匹配的对照组之间慢性自发性荨麻疹（CSU）的风险。本研究的主要目的是利用韩国的国家登记数据评估AITD诊断后CSU的风险。次要目的是评估CSU的其他风险因素。基于2003 - 2005年的疾病编码诊断，我们组成了一个AITD组（n = 3659）和一个年龄及性别匹配的对照组（n = 18295）。对每位患者追踪至2013年，观察是否发生CSU。在调整人口统计学差异和合并症后，AITD患者的CSU发生率显著高于对照组（风险比[HR]，1.46；95%置信区间[CI]，1.25 - 1.70；P < 0.001）。在AITD患者中，桥本甲状腺炎患者CSU的校正HR（HR，1.50）高于格雷夫斯病患者（HR，1.33），尽管差异无统计学意义（P = 0.368）。对与AITD相关的CSU患者分析显示，女性患者CSU风险显著高于男性（HR，1.34；P = 0.001），且患有过敏性鼻炎（HR，1.51；P < 0.001）、特应性皮炎（HR，2.44；P < 0.001）和哮喘（HR，1.50；P < 0.001）的患者CSU风险显著高于无相应疾病的患者。我们的结果表明，AITD可能与CSU风险增加显著相关。
