Lehtinen M, Wigren T, Lehtinen T, Kallioniemi O P, Aine R, Aaran R K, Ojala A
Department of Oncology, Tampere University Central Hospital, Finland.
Tumour Biol. 1988;9(6):287-92. doi: 10.1159/000217574.
We analyzed serum lactate dehydrogenase (LDH), neuron-specific enolase (NSE) and thymidine kinase (TK) levels in 22 patients with small cell lung cancer. Tumor proliferation was expressed as the proportion of S-phase cells (SPF), determined by DNA flow cytometry, from concomitantly taken biopsy samples. A positive correlation between serum NSE (r = 0.41) or LDH (r = 0.65, p = 0.05) levels and tumor SPF was noted, but was not found between serum TK levels and the SPF. The correlation between NSE and SPF was even more pronounced if only patients with extensive disease were considered (r = 0.77). The serum NSE and LDH, but not TK levels, were significantly greater in the patients with extensive disease (NSE 50.4 ng/ml, LDH 621 U/ml) compared to the patients with limited disease (NSE 21.0 ng/ml, LDH 272 U/ml, p = 0.05). Our results suggest that the combined determination of serum LDH and NSE levels gives valuable data on the primary tumor mass and its proliferative activity in small cell lung cancer.
我们分析了22例小细胞肺癌患者的血清乳酸脱氢酶（LDH）、神经元特异性烯醇化酶（NSE）和胸苷激酶（TK）水平。肿瘤增殖以S期细胞比例（SPF）表示，通过对同时采集的活检样本进行DNA流式细胞术测定。血清NSE水平（r = 0.41）或LDH水平（r = 0.65，p = 0.05）与肿瘤SPF之间存在正相关，但血清TK水平与SPF之间未发现相关性。如果仅考虑广泛期疾病患者，NSE与SPF之间的相关性更为明显（r = 0.77）。与局限期疾病患者（NSE 21.0 ng/ml，LDH 272 U/ml，p = 0.05）相比，广泛期疾病患者的血清NSE和LDH水平显著更高（NSE 50.4 ng/ml，LDH 621 U/ml），但TK水平无显著差异。我们的结果表明，联合测定血清LDH和NSE水平可为小细胞肺癌的原发肿瘤大小及其增殖活性提供有价值的数据。
