Cancer Diagnosis & Treatment Center, Kaifeng Central Hospital, Kaifeng 475000, China.
Department of Imaging, Henan Medical College, Zhengzhou 451191, China.
Future Oncol. 2017 Jun;13(13):1173-1180. doi: 10.2217/fon-2016-0437. Epub 2017 May 12.
This study aimed to detect the effect of combination radiotherapy and cantharidin on lung cancer growth. We found that combination therapy with radiotherapy and cantharidin was more effective in inhibiting the tumor growth than radiotherapy or cantharidin alone. It decreased the percentage of CD4 Tregs and enhanced the percentage of CD8 T cells, CD4 Teff cells when comparing to that of single treatment. Combination therapy promoted a great increase in double producing CD8 T cells and CD4 Teff cells in tumor infiltrating lymphocytes. Overexpression of CTLA4 reversed the inhibitory action of combination treatment on cancer growth. Our data suggest that combining radiotherapy and cantharidin may have synergistic effects in driving tumor rejection by increasing T-cell infiltration, proliferation and cytokine production.
本研究旨在检测放疗联合斑蝥素对肺癌生长的影响。我们发现，与单独放疗或斑蝥素治疗相比，放疗联合斑蝥素治疗更能有效抑制肿瘤生长。与单一治疗相比，它降低了 CD4 Tregs 的百分比，并增强了 CD8 T 细胞、CD4 Teff 细胞的百分比。联合治疗促进了肿瘤浸润淋巴细胞中双产 CD8 T 细胞和 CD4 Teff 细胞的大量增加。CTLA4 的过表达逆转了联合治疗对肿瘤生长的抑制作用。我们的数据表明，放疗联合斑蝥素可能通过增加 T 细胞浸润、增殖和细胞因子产生来协同促进肿瘤排斥。
