褪黑素作为一种多功能分子，用于设计针对神经退行性变的新型多靶点杂合物。

Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration.

作者信息

Ramos Eva, Egea Javier, de Los Ríos Cristóbal, Marco-Contelles José, Romero Alejandro

机构信息

Department of Toxicology & Pharmacology, Faculty of Veterinary Medicine, Complutense University of Madrid, 28040 Madrid, Spain.

Instituto de Investigación Sanitaria, Servicio de Farmacología Clínica, Hospital Universitario de la Princesa, 28006 Madrid, Spain.

出版信息

Future Med Chem. 2017 May;9(8):765-780. doi: 10.4155/fmc-2017-0014. Epub 2017 May 12.

DOI:10.4155/fmc-2017-0014

PMID:28498717

Abstract

Melatonin is an indoleamine produced mainly in the pineal gland. The natural decline of melatonin levels with aging strongly contributes to the development of neurodegenerative disorders. Pleiotropic actions displayed by melatonin prevent several processes involved in neurodegeneration such as neuroinflammation, oxidative stress, excitotoxicity and/or apoptosis. This review focuses on a number of melatonin hybrids resulting from the juxtaposition of tacrine, berberine, tamoxifen, curcumin, N,N-dibenzyl(N-methyl)amine, among others, with potential therapeutic effects for the treatment of neurodegenerative diseases.

摘要

褪黑素是一种主要在松果体中产生的吲哚胺。随着年龄增长，褪黑素水平自然下降，这在很大程度上促使神经退行性疾病的发展。褪黑素所表现出的多效性作用可预防神经退行性变涉及的多个过程，如神经炎症、氧化应激、兴奋性毒性和/或细胞凋亡。本综述着重探讨了多种由他克林、黄连素、他莫昔芬、姜黄素、N,N -二苄基（N -甲基）胺等相互结合而成的褪黑素杂合物，这些杂合物对神经退行性疾病的治疗具有潜在的治疗效果。