良好预后却转坏：一名29岁宫颈疣状癌患者的暴发性病情演变

Good Prognosis Went Badly: Fulminant Evolution of a 29-Year-Old Patient with Verrucous Carcinoma of the Cervix.

作者信息

Anghel Rodica M, Trifanescu Oana G, Mitrica Radu I, Curea Fabiana G, Botnariuc Inga, Herghelegiu Catalin G, Orlov Cristina M, Ilie Silvia M

机构信息

1 Department of Radiotherapy II, Institute of Oncology "Prof. Dr. Alexandru Trestioreanu," Bucharest, Romania .

2 University of Medicine and Pharmacy "Carol Davila ," Bucharest, Romania .

出版信息

J Adolesc Young Adult Oncol. 2017 Sep;6(3):499-502. doi: 10.1089/jayao.2017.0009. Epub 2017 May 12.

DOI:10.1089/jayao.2017.0009

PMID:28498727

Abstract

Verrucous carcinoma (VC) is a very rare variant of squamous cell carcinoma of the cervix, difficult to point out in histology because of its benign appearance. We present the case of a 29-year-old woman with a locally advanced cervical VC who underwent radiotherapy followed by radical hysterectomy. After local relapse and despite pelvic exenteration, her condition deteriorated. Treatment of choice in VC is surgery, because of the risk of anaplastic transformation under irradiation, raising the chances of distant spread and converting this rather benign-like type of cancer to an aggressive cancer.

摘要

疣状癌（VC）是宫颈鳞状细胞癌中一种非常罕见的变异类型，因其外观呈良性，在组织学上难以诊断。我们报告一例29岁局部晚期宫颈VC患者，该患者先接受了放疗，随后进行了根治性子宫切除术。局部复发后，尽管进行了盆腔脏器清除术，但其病情仍恶化。由于放疗有间变转化的风险，会增加远处转移的几率，并将这种相当良性的癌症转变为侵袭性癌症，因此VC的首选治疗方法是手术。