Department of Cardiovascular Surgery, Kobe University Hospital, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Japan.
Eur J Cardiothorac Surg. 2017 Jul 1;52(1):112-117. doi: 10.1093/ejcts/ezx034.
We aimed to ascertain the durability of cusp repair techniques used in reimplantation procedures.
Between 2000 and 2015, 249 patients (mean age, 49 ± 17 years) with aortic insufficiency underwent the reimplantation procedure. The pathology was acute aortic dissection in 24 and non-dissection in 225 patients. Preoperative aortic regurgitation (AR) was absent in 9, 1+ in 19, 2+ in 20, 3+ in 71 and 4+ in 120 patients. The mean aortic root and ascending aortic diameters were 47 ± 9 mm and 38 ± 7 mm, respectively. The following techniques of cusp repair were used: none (83), central plication (130), free margin reinforcement (57) and patch repair (19). Annual echocardiography was performed. Freedom from moderate aortic insufficiency and aortic valve reoperation were calculated by the Kaplan-Meier method. Factors influencing the freedom from moderate or severe AR were calculated by proportional hazard analysis.
Mean follow-up period was 56 ± 44 months. Freedom from moderate or severe AR was 82%±3% and 77% ± 4% at 5 and 8 years, respectively, whereas freedom from aortic valve reoperation was 93%±8% and 87% ± 3% at 5 and 8 years, respectively. Recurrent AR and infection were causes of reoperation in 13 and 3 patients, respectively. Preoperative cusp prolapse, technique of free margin reinforcement used and patch repair were significant factors for recurrent AR by proportional hazard analysis. Central plication was not a significant factor for recurrent AR.
Preoperative cusp prolapse was a risk factor, whereas central plication was not a risk factor for recurrent AR. Free margin reinforcement had a positive effect, whereas patch repair had a negative effect on aortic valve durability.
我们旨在确定在再植入手术中使用的瓣叶修复技术的耐久性。
在 2000 年至 2015 年期间,249 名主动脉瓣关闭不全患者(平均年龄,49±17 岁)接受了再植入手术。24 例为急性主动脉夹层,225 例为非夹层。术前主动脉瓣反流(AR)为无(9 例)、1+(19 例)、2+(20 例)、3+(71 例)和 4+(120 例)。平均主动脉根部和升主动脉直径分别为 47±9mm 和 38±7mm。使用了以下几种瓣叶修复技术:无(83 例)、中央折叠(130 例)、游离缘加固(57 例)和补片修复(19 例)。每年进行超声心动图检查。采用 Kaplan-Meier 法计算中度主动脉瓣关闭不全和主动脉瓣再次手术的无失败率。采用比例风险分析计算影响中度或重度 AR 无失败率的因素。
平均随访时间为 56±44 个月。5 年和 8 年时,中度或重度 AR 的无失败率分别为 82%±3%和 77%±4%,而主动脉瓣再次手术的无失败率分别为 93%±8%和 87%±3%。再次手术的原因分别为复发性 AR 和感染。13 例和 3 例因复发性 AR 和感染再次手术。通过比例风险分析,术前瓣叶脱垂、游离缘加固使用的技术和补片修复是复发性 AR 的显著因素。中央折叠不是复发性 AR 的危险因素。
术前瓣叶脱垂是一个危险因素,而中央折叠不是复发性 AR 的危险因素。游离缘加固有积极作用,而补片修复对主动脉瓣耐久性有负面影响。