Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Eur J Cardiothorac Surg. 2017 Oct 1;52(4):823-824. doi: 10.1093/ejcts/ezx151.
Posterior reversible encephalopathy syndrome is a neurological complication associated with calcineurin inhibitors. There is no consensus regarding the continuation of calcineurin inhibitors in the event of posterior reversible encephalopathy syndrome. We report 3 cases of posterior reversible encephalopathy syndrome among 155 lung transplant recipients (1.9%). The calcineurin inhibitor trough level exceeded the therapeutic range in only 1 case. Our findings demonstrate that temporary cessation of calcineurin inhibitors and administration of basiliximab may be effective strategies for managing posterior reversible encephalopathy syndrome.
后部可逆性脑病综合征是一种与钙调神经磷酸酶抑制剂相关的神经系统并发症。对于后部可逆性脑病综合征发生时钙调神经磷酸酶抑制剂是否继续使用，目前尚无共识。我们报告了 155 例肺移植受者中的 3 例（1.9%）后部可逆性脑病综合征。仅 1 例钙调神经磷酸酶抑制剂谷浓度超过治疗范围。我们的研究结果表明，暂时停用钙调神经磷酸酶抑制剂和给予巴利昔单抗可能是治疗后部可逆性脑病综合征的有效策略。
