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Organization of the gene encoding the insulin-like growth factor binding protein IBP-1.

作者信息

Brinkman A, Groffen C A, Kortleve D J, Drop S L

机构信息

Department of Pediatrics, Erasmus University/Sophia Childrens Hospital, Rotterdam, The Netherlands.

出版信息

Biochem Biophys Res Commun. 1988 Dec 30;157(3):898-907. doi: 10.1016/s0006-291x(88)80959-8.

DOI:10.1016/s0006-291x(88)80959-8
PMID:2849945
Abstract

Human genomic clones encompassing the tissue specific expressed gene IBP-1, an insulin-like growth factor binding protein were isolated and characterized. The gene is organized in four exons and spans 5.9 kb. S1 nuclease analysis determined a single transcription start site. The first exon and 5' flanking region are highly GC rich and located in a CpG island. The CpG island enclose the CAAT box, the TATA box, the transcription start site and a potential SP1 transcription factor binding site. The presumptive promoter region is characteristic for genes expressed in a tissue specific fashion. All signals required for cleavage/polyadenylation are located within exon IV, predicting a mRNA of 1.5 kb which is consistent with the size seen on RNA blots.

摘要

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The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12-p13 and description of a DNA polymorphism.编码人低分子量胰岛素样生长因子结合蛋白（IGF-BP25）的基因：定位于7p12-p13区域及一种DNA多态性的描述
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