Sanches Maria Mendonça, Travassos Ana Rita, Soares-de-Almeida Luis
Serviço de Dermatologia. Hospital de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. Portugal.
Serviço de Dermatologia. Hospital de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. Portugal; Centro de Dermatologia. Hospital CUF Descobertas. Lisboa. Portugal.
Acta Med Port. 2017 Jan 31;30(1):69-72. doi: 10.20344/amp.7997.
The effects of immunodepression on several disease states have constituted an important area of research, leading to the identification of relevant associations between immunodepression and a vast set of comorbidities, including infectious diseases, cardiovascular diseases and cancer. Research on the effects of immunodepression has mostly been conducted in individuals under immunodepression by the human immunodeficiency virus and transplant recipients under pharmacological immunosuppression, due to the difficulties in obtaining relevant samples sizes in other contexts of immunodepression. Overall, immunosuppressed individuals tend to show increased incidence of malignancies, but only transplant recipients show significantly increased incidence of skin cancer; human immunodeficiency virus-infected individuals only show increased incidence of malignancies of infectious origin. This paper presents a literature review on the effects of immunodepression in the development of tumours in humans, with special emphasis on the development of the different types of skin cancer.
免疫抑制对多种疾病状态的影响已构成一个重要的研究领域，从而确定了免疫抑制与大量共病之间的相关关联，这些共病包括传染病、心血管疾病和癌症。由于在其他免疫抑制情况下难以获得相关样本量，关于免疫抑制影响的研究大多在感染人类免疫缺陷病毒的免疫抑制个体以及接受药物免疫抑制的移植受者中进行。总体而言，免疫抑制个体往往表现出恶性肿瘤发病率增加，但只有移植受者的皮肤癌发病率显著增加；感染人类免疫缺陷病毒的个体仅表现出感染源性恶性肿瘤发病率增加。本文对免疫抑制在人类肿瘤发生中的影响进行了文献综述，特别强调了不同类型皮肤癌的发生情况。
