Niemann Adam C, Reid Alexander T, Smith Joshua, Hammond James, DeBolle Stephanie A, Wei Iris, Soong-Ho Lee Christopher, Hughes David T
Department of Surgery, University of Michigan, Ann Arbor, Michigan.
Department of Surgery, University of Michigan, Ann Arbor, Michigan.
J Surg Res. 2017 May 1;211:228-232. doi: 10.1016/j.jss.2016.12.021. Epub 2016 Dec 30.
Certain patient demographics and histopathologic features are risk factors for papillary thyroid cancer (PTC) recurrence after initial treatment. Our objective was to determine whether very young age is associated with aggressive pathologic features in patients with PTC.
A retrospective analysis was performed for PTC patients who underwent surgical treatment at the University of Michigan between 2006 and 2012. Patients with known distant metastases were excluded. Demographics, high-risk pathologic features (capsular or vascular invasion, extrathyroidal extension, lymph node metastases, and extranodal extension), and disease recurrence were analyzed.
632 PTC patients were included in the analysis. Median age was 49 y (range 10-87). Tumors in patients aged <25 y had higher rates of extranodal extension (P = 0.002) compared with patients aged 25-44 y. Patients aged <25 y had more vascular invasion (P < 0.001) and lymph node metastasis (P = 0.001) than tumors in patients aged between 45-75 y. Patients aged >75 y had higher rates of vascular invasion (P < 0.001) and extrathyroidal extension (P = 0.001) compared with patients aged 45-75 y and more extrathyroidal extension (P < 0.001) than patients aged 25-44 y. There were no differences in tumor characteristics between the <25 and >75 age groups.
PTC patients aged <25 y of age or older than 75 y exhibit higher rates of aggressive histopathologic features compared to PTC patients aged between 25-75 y.
某些患者人口统计学特征和组织病理学特征是甲状腺乳头状癌（PTC）初始治疗后复发的危险因素。我们的目的是确定非常年轻的年龄是否与PTC患者的侵袭性病理特征相关。
对2006年至2012年在密歇根大学接受手术治疗的PTC患者进行回顾性分析。排除已知有远处转移的患者。分析患者人口统计学特征、高危病理特征（包膜或血管侵犯、甲状腺外扩展、淋巴结转移和结外扩展）及疾病复发情况。
632例PTC患者纳入分析。中位年龄为49岁（范围10 - 87岁）。与25 - 44岁的患者相比，年龄<25岁患者的肿瘤结外扩展发生率更高（P = 0.002）。年龄<25岁的患者比45 - 75岁患者的肿瘤有更多的血管侵犯（P < 0.001）和淋巴结转移（P = 0.001）。与45 - 75岁的患者相比，年龄>75岁的患者血管侵犯发生率更高（P < 0.001），甲状腺外扩展发生率更高（P = 0.001），且比25 - 44岁的患者有更多的甲状腺外扩展（P < 0.001）。年龄<25岁和>75岁的年龄组之间肿瘤特征无差异。
与年龄在25 - 75岁之间的PTC患者相比，年龄<25岁或>75岁的PTC患者具有更高的侵袭性组织病理学特征发生率。
