酒精相关性痴呆：流行病学研究的系统评价
Alcohol-Related Dementia: A Systemic Review of Epidemiological Studies.
作者信息
Cheng Chin, Huang Chieh-Liang, Tsai Chia-Jui, Chou Po-Han, Lin Chih-Chien, Chang Chin-Kuo
机构信息
Department of Psychiatry, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taiwan.
出版信息
Psychosomatics. 2017 Jul-Aug;58(4):331-342. doi: 10.1016/j.psym.2017.02.012. Epub 2017 Mar 1.
BACKGROUND
Alcohol-related dementia (ARD) is a heterogeneous long-term cognitive problem that can develop in the course of alcoholism. Current understanding of ARD remains limited.
METHODS
We conducted a systematic review to synthesize available data on the epidemiology of ARD, through searching the relevant studies in the PubMed, PsycINFO, and ALOIS. "Alcohol" and "dementia" were used as keywords.
RESULTS
We included articles published between January 1, 1991 and February 29, 2016, where language was not limited. Of the 9 identified articles, the prevalence of ARD ranged from 1.19/1000 in multiday admission patients residing in the United Kingdom to 25.6% in elderly clinic alcoholics from the United States. The proportion of ARD in early-onset dementia taken from 3 studies was approximately 10%, whereas only 1.28% in late-onset dementia taken from 1 study.
CONCLUSIONS
Considering the relatively high proportion of ARD in early-onset dementia and its potentially reversible course, future investigation into ARD is necessary.
背景
酒精相关痴呆（ARD）是一种异质性的长期认知问题，可在酗酒过程中发生。目前对ARD的认识仍然有限。
方法
我们进行了一项系统综述，通过检索PubMed、PsycINFO和ALOIS中的相关研究，综合有关ARD流行病学的现有数据。以“酒精”和“痴呆”作为关键词。
结果
我们纳入了1991年1月1日至2016年2月29日期间发表的文章，不限语言。在9篇纳入的文章中，ARD的患病率在英国多日住院患者中为1.19/1000，在美国老年门诊酗酒者中为25.6%。来自3项研究的早发性痴呆中ARD的比例约为10%，而来自1项研究的晚发性痴呆中仅为1.28%。
结论
鉴于早发性痴呆中ARD的比例相对较高及其潜在的可逆病程，未来有必要对ARD进行研究。
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