蛙皮素（一种八肽胆囊收缩素样肽）对人体垂体肾上腺皮质系统的刺激作用。
Stimulation of the pituitary adrenocortical system in man by cerulein, a cholecystokinin-8-like peptide.
作者信息
Späth-Schwalbe E, Piroth L, Pietrowsky R, Born J, Fehm H L
机构信息
Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik, Universität Ulm, BRD.
出版信息
Clin Physiol Biochem. 1988;6(6):316-20.
The responses of plasma adrenocorticotropin hormone (ACTH) and cortisol to intravenous injection of cerulein (ceruletide), a decapeptide closely related to cholecystokinin octapeptide, were investigated in healthy men. In response to 16 ng/kg cerulein, plasma ACTH rose from a preinjection level of 42 +/- 11 pg/ml (mean +/- SEM) to a peak level of 81 +/- 16 pg/ml after 15 min. This ACTH increase was followed by a rise in plasma cortisol from a preinjection value of 10.3 +/- 0.9 microgram/dl to a peak value of 17.7 +/- 1.7 microgram/dl after 30 min. This is the first report of the potent stimulating effect of a cholecystokinin-8-related peptide on the pituitary-adrenal system in man.
在健康男性中，研究了血浆促肾上腺皮质激素（ACTH）和皮质醇对静脉注射雨蛙肽（ceruletide，一种与八肽胆囊收缩素密切相关的十肽）的反应。静脉注射16 ng/kg雨蛙肽后，血浆促肾上腺皮质激素在15分钟内从注射前的42±11 pg/ml（平均值±标准误）升至峰值81±16 pg/ml。促肾上腺皮质激素升高后，血浆皮质醇在30分钟内从注射前的10.3±0.9 μg/dl升至峰值17.7±1.7 μg/dl。这是关于一种与胆囊收缩素-8相关的肽对人体垂体-肾上腺系统具有强效刺激作用的首次报道。
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