Division of Nephrology, Albert Einstein College of Medicine, Bronx, New York, USA.
Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan.
Kidney Int. 2017 Jun;91(6):1269-1271. doi: 10.1016/j.kint.2017.04.001.
Angiotensin-converting enzyme 2 cleaves angiotensin (Ang) II to Ang(1-7), which antagonizes the deleterious effects of Ang II. In this issue, 2 groups administered angiotensin-converting enzyme 2 in murine models of kidney disease. Angiotensin-converting enzyme 2 did not improve glomerular injury in 2 models of mild diabetic nephropathy but was partially protective in an Alport syndrome model. These discrepant findings may be explained by the inability of angiotensin-converting enzyme 2 to reach the urinary space in the absence of severe proteinuria.
血管紧张素转换酶 2 将血管紧张素（Ang）II 切割成 Ang（1-7），从而拮抗 Ang II 的有害作用。在本期杂志中，有 2 个研究小组在肾脏疾病的小鼠模型中给予血管紧张素转换酶 2。血管紧张素转换酶 2 并没有改善 2 种轻度糖尿病肾病模型中的肾小球损伤，但在 Alport 综合征模型中具有部分保护作用。这些不一致的发现可能是由于在没有严重蛋白尿的情况下，血管紧张素转换酶 2 无法到达尿空间所导致的。
