Renal Division, Department of Internal Medicine, Ghent University Hospital, Gent, Belgium.
Renal Division, Department of Internal Medicine, Ghent University Hospital, Gent, Belgium.
Kidney Int. 2017 Jun;91(6):1271-1274. doi: 10.1016/j.kint.2017.02.025.
Patients with atypical hemolytic uremic syndrome (aHUS) and malignant hypertension can both present with concomitant hypertension and thrombotic microangiopathy (TMA), rendering policy decisions complex. Timmermans et al. report that patients with severe hypertension and renal TMA might have unrecognized aHUS with underlying complement abnormalities. Based on this, they assert that all patients presenting with severe hypertension and renal TMA should be evaluated for aHUS. It remains uncertain whether this holds equally true for patients with malignant hypertension and renal TMA.
患有非典型溶血性尿毒症综合征 (aHUS) 和恶性高血压的患者均可同时出现高血压和血栓性微血管病 (TMA)，这使得决策变得复杂。Timmermans 等人报告说，严重高血压和肾 TMA 的患者可能存在未被识别的补体异常的 aHUS。基于此，他们断言所有出现严重高血压和肾 TMA 的患者都应评估是否患有 aHUS。对于恶性高血压和肾 TMA 的患者，这种情况是否同样适用仍不确定。
