切应力对裂孔隔膜和足细胞功能的潜在相关性。
Potential relevance of shear stress for slit diaphragm and podocyte function.
机构信息
Department of Neuroanatomy, Medical Faculty Mannheim, Germany.
Division of Nephrology, Children's Hospital Los Angeles, California, USA.
出版信息
Kidney Int. 2017 Jun;91(6):1283-1286. doi: 10.1016/j.kint.2017.02.032.
PMID:28501303
Abstract
Filtrate flow through the glomerular barrier produces shear stresses that tend to disconnect podocytes from the glomerular basement membrane. Forces are highest within the filtration slits. The slit diaphragm mechanically balances the lateral components of the shear stresses on opposing foot processes, preventing widening of the slit.
摘要
滤过液流经肾小球屏障会产生剪切力，这种力往往会使足细胞从肾小球基底膜上脱离。剪切力在滤过裂隙内最大。裂孔隔膜在机械上平衡了作用于相对足突的剪切力的侧向分量，防止了裂隙的增宽。
Zotero 插件