Department of Neuroanatomy, Medical Faculty Mannheim, Germany.
Division of Nephrology, Children's Hospital Los Angeles, California, USA.
Kidney Int. 2017 Jun;91(6):1283-1286. doi: 10.1016/j.kint.2017.02.032.
Filtrate flow through the glomerular barrier produces shear stresses that tend to disconnect podocytes from the glomerular basement membrane. Forces are highest within the filtration slits. The slit diaphragm mechanically balances the lateral components of the shear stresses on opposing foot processes, preventing widening of the slit.
滤过液流经肾小球屏障会产生剪切力，这种力往往会使足细胞从肾小球基底膜上脱离。剪切力在滤过裂隙内最大。裂孔隔膜在机械上平衡了作用于相对足突的剪切力的侧向分量，防止了裂隙的增宽。
