性别不匹配的心脏移植受者的死亡率、再次住院率及移植后并发症
Mortality, rehospitalization, and post-transplant complications in gender-mismatched heart transplant recipients.
作者信息
Jalowiec Anne, Grady Kathleen L, White-Williams Connie
机构信息
School of Nursing, Loyola University, Chicago, IL, USA.
Center for Heart Failure, Bluhm Cardiovascular Institute, Division of Cardiac Surgery, Northwestern Memorial Hospital, Chicago, IL, USA; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
出版信息
Heart Lung. 2017 Jul-Aug;46(4):265-272. doi: 10.1016/j.hrtlng.2017.04.004. Epub 2017 May 10.
BACKGROUND
Limited research has been published on outcomes in heart transplant (HT) recipients with gender-mismatched donors.
OBJECTIVE
Compare 3-year post-transplant outcomes in 2 groups of gender-mismatched HT recipients and a no-mismatch group.
METHODS
Sample: 347 HT recipients: 21.3% (74) received a heart from the opposite gender: Group 1: same gender donor/recipient (273, 78.7%); Group 2: female donor/male recipient (40, 11.5%); Group 3: male donor/female recipient (34, 9.8%).
OUTCOMES
mortality, hospitalization, and complications.
RESULTS
Female patients with male heart donors had shorter 3-year survival, were rehospitalized more days after HT discharge, and had more treated acute rejection episodes and cardiac allograft vasculopathy. No differences were found in: HT length of stay, respiratory failure, stroke, cancer, renal dysfunction, steroid-induced diabetes, number of IV-treated infections, or the timing of infection and rejection.
CONCLUSION
Female HT recipients with male donors had worse 3-year outcomes as compared to male-mismatch and no-mismatch groups.
背景
关于接受性别不匹配供体心脏移植（HT）受者的预后情况，发表的研究有限。
目的
比较两组性别不匹配的HT受者和一组性别匹配的受者移植后3年的预后情况。
方法
样本：347名HT受者：21.3%（74名）接受了异性心脏：第1组：同性供体/受者（273名，78.7%）；第2组：女性供体/男性受者（40名，11.5%）；第3组：男性供体/女性受者（34名，9.8%）。
结果
接受男性心脏供体的女性患者3年生存率较低，HT出院后再次住院天数更多，急性排斥反应治疗发作次数更多，且发生心脏移植血管病变更多。在以下方面未发现差异：HT住院时间、呼吸衰竭、中风、癌症、肾功能不全、类固醇诱导的糖尿病、静脉注射治疗感染的次数，或感染和排斥反应的发生时间。
结论
与男性不匹配组和匹配组相比，接受男性供体的女性HT受者3年预后更差。
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