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参与地中海红珊瑚（Corallium rubrum）生物矿化的一种α-碳酸酐酶（CruCA4）的动力学特性及对磺胺类抑制剂的亲和力。

Kinetic properties and affinities for sulfonamide inhibitors of an α-carbonic anhydrase (CruCA4) involved in coral biomineralization in the Mediterranean red coral Corallium rubrum.

作者信息

Del Prete Sonia, Vullo Daniela, Zoccola Didier, Tambutté Sylvie, Capasso Clemente, Supuran Claudiu T

机构信息

Istituto di Bioscienze e Biorisorse, CNR, Via Pietro Castellino 111, Napoli, Italy; Università degli Studi di Firenze, Dipartimento Di Chimica, Laboratorio di Chimica Bioinorganica, Polo Scientifico, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy.

Università degli Studi di Firenze, Dipartimento Di Chimica, Laboratorio di Chimica Bioinorganica, Polo Scientifico, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy.

出版信息

Bioorg Med Chem. 2017 Jul 1;25(13):3525-3530. doi: 10.1016/j.bmc.2017.05.001. Epub 2017 May 3.

DOI:10.1016/j.bmc.2017.05.001
PMID:28501430
Abstract

We report the kinetic properties and sulfonamide inhibition profile of an α-carbonic anhydrase (CA, EC 4.2.1.1), named CruCA4, identified in the red coral Corallium rubrum. This isoform is involved in the biomineralization process leading to the formation of a calcium carbonate skeleton. Experiments performed on the recombinant protein show that the enzyme has a "moderate activity" level. Our results are discussed compared to values obtained for other CA isoforms involved in biomineralization. This is the first study describing the biochemical characterization of an octocoral CA.

摘要

我们报告了在红珊瑚红珊瑚（Corallium rubrum）中鉴定出的一种α-碳酸酐酶（CA，EC 4.2.1.1），即CruCA4的动力学特性和磺胺类抑制谱。这种同工型参与导致碳酸钙骨架形成的生物矿化过程。对重组蛋白进行的实验表明，该酶具有“中等活性”水平。我们将结果与参与生物矿化的其他CA同工型所获得的值进行了比较讨论。这是第一项描述八放珊瑚CA生化特性的研究。

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