习惯性运动水平与无症状常染色体显性阿尔茨海默病患者的脑淀粉样蛋白负荷有关。
Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease.
机构信息
School of Psychology and Exercise Science, Murdoch University, Murdoch, Western Australia, Australia; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; McCusker Alzheimer's Research Foundation, Nedlands, Western Australia, Australia.
Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; McCusker Alzheimer's Research Foundation, Nedlands, Western Australia, Australia.
出版信息
Alzheimers Dement. 2017 Nov;13(11):1197-1206. doi: 10.1016/j.jalz.2017.03.008. Epub 2017 May 11.
INTRODUCTION
The objective of this study was to evaluate the relationship between self-reported exercise levels and Alzheimer's disease (AD) biomarkers, in a cohort of autosomal dominant AD mutation carriers.
METHODS
In 139 presymptomatic mutation carriers from the Dominantly Inherited Alzheimer Network, the relationship between self-reported exercise levels and brain amyloid load, cerebrospinal fluid (CSF) Aβ and CSF tau levels was evaluated using linear regression.
RESULTS
No differences in brain amyloid load, CSF Aβ, or CSF tau were observed between low and high exercise groups. Nevertheless, when examining only those already accumulating AD pathology (i.e., amyloid positive), low exercisers had higher mean levels of brain amyloid than high exercisers. Furthermore, the interaction between exercise and estimated years from expected symptom onset was a significant predictor of brain amyloid levels.
DISCUSSION
Our findings indicate a relationship exists between self-reported exercise levels and brain amyloid in autosomal dominant AD mutation carriers.
简介
本研究旨在评估 139 名常染色体显性遗传 AD 突变携带者的自我报告运动水平与阿尔茨海默病（AD）生物标志物之间的关系。
方法
在来自显性遗传性阿尔茨海默病网络的 139 名无症状前突变携带者中，使用线性回归评估自我报告的运动水平与脑淀粉样蛋白负荷、脑脊液（CSF）Aβ和 CSF tau 水平之间的关系。
结果
低运动组和高运动组之间的脑淀粉样蛋白负荷、CSF Aβ或 CSF tau 无差异。然而，当仅检查已经积累 AD 病理的个体（即淀粉样蛋白阳性）时，低运动者的脑淀粉样蛋白水平高于高运动者。此外，运动与预计发病前的时间的交互作用是脑淀粉样蛋白水平的一个显著预测因子。
讨论
我们的发现表明，在常染色体显性遗传 AD 突变携带者中，自我报告的运动水平与脑淀粉样蛋白之间存在关系。
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