Berman Melissa, Dubé Eve, Quach Caroline
Department of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, QC, Canada; MUHC Vaccine Study Centre - Research Institute, McGill University Health Centre, Montreal, QC, Canada.
Direction des risques biologiques et de la santé au travail, Institut national de santé publique du Québec, Quebec City, QC, Canada.
Vaccine. 2017 Jun 5;35(25):3326-3332. doi: 10.1016/j.vaccine.2017.04.083. Epub 2017 May 10.
In children, the 13 and 10-valent pneumoccocal conjugate vaccines (PCV13/10) are currently approved for the prevention of invasive pneumococcal disease (IPD). Acceptability is a key consideration in the implementation of a vaccine program and it is recognized that health professional's attitudes and opinions towards vaccines are independent predictors of the success of an immunization program. We aimed to survey the beliefs and attitudes for the two available PCVs in health care professionals and immunization experts.
We interviewed 21 members of Canadian immunization committees and/or participants working in frontline healthcare delivery. Overall, participants predominantly preferred PCV-13 over PCV10. For most, AOM should not be taken into considerations in decisions for pneumococcal vaccination programs implementation. AOM was considered an important endpoint of the program but an ineffective measure of program success due to the lack of surveillance for the condition. Recent evidence pertaining to PCV10 cross-protection against 19A did not affect preference but had an impact on perceptions regarding pricing.
To consider implementing any changes to the current program, most participants would require more evidence regarding PCV10 cross-protection and effectiveness against OM. Decreasing vaccine price was cited as a positive outcome of funding both vaccines.
在儿童中,13价和10价肺炎球菌结合疫苗(PCV13/10)目前已被批准用于预防侵袭性肺炎球菌疾病(IPD)。可接受性是疫苗计划实施中的一个关键考虑因素,并且人们认识到医疗保健专业人员对疫苗的态度和看法是免疫计划成功的独立预测因素。我们旨在调查医疗保健专业人员和免疫专家对两种可用肺炎球菌结合疫苗的信念和态度。
我们采访了加拿大免疫委员会的21名成员和/或在一线医疗保健服务中工作的参与者。总体而言,参与者主要更喜欢PCV-13而非PCV10。对于大多数人来说,在实施肺炎球菌疫苗接种计划的决策中不应考虑急性中耳炎(AOM)。AOM被认为是该计划的一个重要终点,但由于缺乏对该病症的监测,它不是衡量计划成功的有效指标。近期有关PCV10对19A血清型交叉保护作用的证据并未影响偏好,但对价格认知产生了影响。
为了考虑对当前计划进行任何更改,大多数参与者将需要更多关于PCV10交叉保护作用和对中耳炎有效性的证据。降低疫苗价格被认为是为两种疫苗提供资金的一个积极成果。