Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu, China.
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu, China.
Pharmacol Res. 2017 Dec;126:97-108. doi: 10.1016/j.phrs.2017.05.004. Epub 2017 May 10.
Tumor microenvironment (TME) plays a critical role in tumorigenesis, tumor invasion and metastasis. TME is composed of stroma, endothelial cells, pericytes, fibroblasts, smooth muscle cells, and immune cells, which is characterized by hypoxia, acidosis, and high interstitial fluid pressure. Due to the important role of TME, we firstly reviewed the composition of TME and discussed the impact of TME on tumor progression, drug and nanoparticle delivery. Next, we reviewed current strategies developed to modulate TME, including modulating tumor vasculature permeability, tumor associated macrophage phenotypes, tumor associated fibroblasts, tumor stroma components, tumor hypoxia, and multiple interventions simultaneously. Also, potential problems and future directions of TME modulation strategy have been discussed.
肿瘤微环境（TME）在肿瘤发生、肿瘤侵袭和转移中起着关键作用。TME 由基质、内皮细胞、周细胞、成纤维细胞、平滑肌细胞和免疫细胞组成，其特点是缺氧、酸中毒和高细胞外液压力。由于 TME 的重要作用，我们首先综述了 TME 的组成，并讨论了 TME 对肿瘤进展、药物和纳米颗粒递送的影响。接下来，我们综述了目前开发的调节 TME 的策略，包括调节肿瘤血管通透性、肿瘤相关巨噬细胞表型、肿瘤相关成纤维细胞、肿瘤基质成分、肿瘤缺氧以及同时进行多种干预。此外，还讨论了 TME 调节策略的潜在问题和未来方向。
