Tumour Host Interaction Laboratory, The Francis Crick Institute, 1 Midland Rd, NW1 1AT London, UK.
Tumour Host Interaction Laboratory, The Francis Crick Institute, 1 Midland Rd, NW1 1AT London, UK.
Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):231-238. doi: 10.1016/j.bbcan.2017.05.002. Epub 2017 May 10.
Metastasis is the main cause of death for most cancer patients. It appears clear from clinical observations that the majority of cancers, particularly carcinoma do not follow a linear model of metastatic progression, where cancer cells shed from the primary tumour, disseminate to a distant organ and immediately outgrow to form clinical metastasis. Certainly, while cancer spreading is an early event, metastasis occurs much later during tumour progression and frequently arises several years after primary tumour resection. The time spent by disseminated cancer cells (DTCs) in a distant organ before their outgrowth is termed metastatic latency. We will examine here the current knowledge of the mechanisms allowing metastatic latency and discuss the crucial role of the DTCs' tissue microenvironment in this process.
转移是大多数癌症患者死亡的主要原因。从临床观察来看，很明显，大多数癌症，特别是癌，并不遵循转移性进展的线性模型，即癌细胞从原发性肿瘤脱落，扩散到远处器官，并立即过度生长形成临床转移。当然，虽然癌症扩散是早期事件，但转移发生在肿瘤进展的后期，并且通常在原发性肿瘤切除后数年才发生。在远处器官中扩散的癌细胞（DTCs）过度生长之前所经历的时间称为转移潜伏期。我们将在这里检查目前对允许转移潜伏期的机制的了解，并讨论 DTCs 组织微环境在这个过程中的关键作用。
