下肢浅静脉血栓形成患者中血栓形成倾向疾病的意外高发生率。
An Unexpectedly High Rate of Thrombophilia Disorders in Patients with Superficial Vein Thrombosis of the Lower Extremities.
作者信息
Sobreira Marcone Lima, Rogatto Silvia Regina, Dos Santos Rodrigo Mattos, Santos Izolete Thomazini, Ferrari Iracema Carvalho, Yoshida Winston Bonetti
机构信息
Division of Vascular and Endovascular Surgery, Department of Surgery and Orthpedics, Botucatu Medical School, UNESP, Botucatu, São Paulo, Brazil.
Department of Urology, Botucatu Medical School, UNESP, Botucatu, São Paulo, Brazil.
出版信息
Ann Vasc Surg. 2017 Aug;43:272-277. doi: 10.1016/j.avsg.2017.02.022. Epub 2017 May 10.
BACKGROUND
Superficial vein thrombosis (SVT) is a common venous condition. Recent studies have shown that SVT is associated with high frequency of thromboembolic complications: from 22-37% for deep venous thrombosis and up to 33% for pulmonary embolism. Our goal was to assess the prevalence of major hereditary and acquired thrombophilic factors in patients with SVT.
METHODS
Sixty-six patients presenting with primary SVT underwent evaluation for thrombophilia: molecular testing for the factor V Leiden and factor II G20210 A (prothrombin) mutations, protein C, protein S, antithrombin deficiency, presence of lupus anticoagulant, as well as anticardiolipin antibody titers. Patients aged less than 18 years, with confirmed deep vein thrombosis, and pregnant women were excluded.
RESULTS
95.5% were Caucasian, and 62.1% were female gender. Age ranged from 21-88 years. Molecular testing showed that 34.2% of patients were heterozygous for factor V Leiden, 23.6% were heterozygous for the factor II mutation, 7.8% had antithrombin deficiency, 2.6% had protein S deficiency, and 2.1% had protein C deficiency.
CONCLUSIONS
Our study showed that hereditary and acquired thrombophilias are higher than previously expected and reported.
背景
浅静脉血栓形成（SVT）是一种常见的静脉疾病。最近的研究表明，SVT与血栓栓塞并发症的高发生率相关：深静脉血栓形成的发生率为22%-37%，肺栓塞的发生率高达33%。我们的目标是评估SVT患者中主要遗传性和获得性血栓形成倾向因素的患病率。
方法
对66例原发性SVT患者进行血栓形成倾向评估：检测因子V Leiden和因子II G20210A（凝血酶原）突变、蛋白C、蛋白S、抗凝血酶缺乏、狼疮抗凝物的存在以及抗心磷脂抗体滴度。排除年龄小于18岁、确诊为深静脉血栓形成的患者以及孕妇。
结果
95.5%为白种人，62.1%为女性。年龄范围为21-88岁。分子检测显示，34.2%的患者因子V Leiden杂合，23.6%的患者因子II突变杂合，7.8%的患者抗凝血酶缺乏，2.6%的患者蛋白S缺乏，2.1%的患者蛋白C缺乏。
结论
我们的研究表明，遗传性和获得性血栓形成倾向高于先前预期和报道。
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