Spijkers Suzanne, Lens Jan Willem, Schats Roel, Lambalk Cornelis B
VU University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Medicine, Amsterdam, The Netherlands.
Gynecol Obstet Invest. 2017;82(6):538-546. doi: 10.1159/000468935. Epub 2017 May 13.
BACKGROUND/AIM: To compare the pregnancy outcome of singletons conceived after transfer of cryopreserved and thawed embryos (frozen embryo transfer [FET]) to singletons conceived after fresh embryo transfer (fresh ET) and natural conceived singletons.
Using a retrospective data analysis on a study population consisting of 1,261 singletons born after FET and 2,519 singletons born after fresh ET between 2006 and 2015. The control group consisted of singletons born after natural conception. Main outcome measures consisted of birth weight (in grams), gestational age, preterm birth (<37 weeks of gestation), being large for gestational age (LGA, above 90th weight percentile adjusted for gestational age) and Apgar scores.
Babies born after FET had an increased risk of high birth weight (adjusted OR [AOR]) 2.92; 1.503-3.482) and being LGA (AOR fresh ET vs. FET 1.47; 1.210-1.787) compared to singletons born after fresh ET, as well as higher birth weights compared to natural conceived children.
Singletons born after FET have a higher risk of high birth weight and being LGA compared to singletons after fresh ET and compared to natural conceived singletons. We assume that the freezing process might be the underlying cause.
背景/目的：比较冷冻解冻胚胎移植（FET）后受孕的单胎妊娠结局与新鲜胚胎移植（新鲜ET）后受孕的单胎以及自然受孕单胎的妊娠结局。
对2006年至2015年间1261例FET后出生的单胎和2519例新鲜ET后出生的单胎组成的研究人群进行回顾性数据分析。对照组由自然受孕后出生的单胎组成。主要观察指标包括出生体重（克）、孕周、早产（妊娠<37周）、大于胎龄儿（LGA，出生体重高于根据孕周调整后的第90百分位数）和阿氏评分。
与新鲜ET后出生的单胎相比，FET后出生的婴儿出生体重高的风险增加（调整后比值比[AOR] 2.92；1.503 - 3.482），且为LGA的风险增加（新鲜ET与FET相比的AOR 1.47；1.210 - 1.787），与自然受孕的儿童相比出生体重也更高。
与新鲜ET后出生的单胎以及自然受孕的单胎相比，FET后出生的单胎出生体重高和为LGA的风险更高。我们认为冷冻过程可能是潜在原因。
