Cannavò S, Li Calzi L, Aragona A, Trimarchi F
Istituto di Clinica Medica e Terapia Medica, Università di Messina, School of Medicine, Italy.
J Endocrinol Invest. 1988 Jun;11(6):425-8. doi: 10.1007/BF03349075.
Abnormalities in hypothalamic-pituitary adrenal axis function were demonstrated by measuring plasma adrenocorticotropin abnormal concentrations following Vasoactive Intestinal Peptide (VIP) and Corticotropin Releasing Hormone (CRH) administration during a phase of remission of Cushing's disease in a 45-year-old female patient. When observed 80 days after the first examination, the patient no longer showed cushingoid features and serum cortisol and plasma ACTH were not abnormally high. VIP infusion (75 micrograms during 12 min) induced a significant increase in serum cortisol and ACTH plasma levels with respect to the normal unresponsiveness. Exaggerated plasma ACTH response to CRH (50 micrograms iv) was also observed. We conclude that the study of ACTH and cortisol response to VIP and CRH may be useful in revealing Cushing's disease even during a remission phase of the disorder.
通过在一名45岁女性库欣病缓解期给予血管活性肠肽（VIP）和促肾上腺皮质激素释放激素（CRH）后测量血浆促肾上腺皮质激素异常浓度，证实了下丘脑 - 垂体 - 肾上腺轴功能异常。在首次检查80天后观察发现，该患者不再表现出库欣样特征，血清皮质醇和血浆促肾上腺皮质激素也未异常升高。与正常无反应情况相比，VIP输注（12分钟内输注75微克）导致血清皮质醇和血浆促肾上腺皮质激素水平显著升高。还观察到血浆促肾上腺皮质激素对CRH（静脉注射50微克）的反应过度。我们得出结论，研究促肾上腺皮质激素和皮质醇对VIP和CRH的反应可能有助于揭示库欣病，即使在该疾病的缓解期也是如此。
