Pangui E, Chevrant-Breton O, Berrada A, Philippe H J, Kerisit J, Giraud J R, Grall J Y
Service de Gynécologie-Obstétrique, C.H.R. de Rennes.
J Gynecol Obstet Biol Reprod (Paris). 1988;17(4):491-4.
In France, 7,000 women die yearly of cancer of the breast, and 25,000 new cases are registered. The seriousness of the illness and its frequency show how important it is to diagnose it early at a stage before invasion or in situ (where 95 to 100% can be cured). In 4 years, at the University Hospital of Rennes, 90 out of 446 patients who were operated on for breast lesions had invasive cancer of the breast, i.e. 20%. 12 had a carcinoma in situ of the breast (C.I.S.E.), constituting 2.6%, of which 9 were in situ duct carcinomas and 3 in situ lobular carcinomas. In situ carcinoma of the breast can take almost any clinical form (a nodule, pain in the breast, mastitis, blood stained discharge from the nipple or Paget's disease). This means that lobular carcinoma in situ is always a surprise when diagnosed histologically in a lesion that is clinically benign. Since the anatomo-pathological diagnosis is difficult, a simple examination of the breast is not to be relied on in cases of carcinoma in situ of the breast. Mammography is the only truly valuable investigation in early diagnosis of C.I.S.E.
在法国，每年有7000名女性死于乳腺癌，并有25000例新病例登记在册。这种疾病的严重性及其高发性表明，在侵袭前或原位阶段（95%至100%的此类病例可治愈）早期诊断是多么重要。在4年时间里，在雷恩大学医院，446例因乳腺病变接受手术的患者中，有90例患有浸润性乳腺癌，即20%。12例患有乳腺原位癌（C.I.S.E.），占2.6%，其中9例为导管原位癌，3例为小叶原位癌。乳腺原位癌几乎可以呈现任何临床症状（结节、乳房疼痛、乳腺炎、乳头血性溢液或佩吉特病）。这意味着，当在临床诊断为良性的病变中通过组织学检查诊断出小叶原位癌时，总会令人感到意外。由于解剖病理学诊断困难，对于乳腺原位癌病例，不能仅依靠简单的乳房检查。乳房X光造影是早期诊断乳腺原位癌唯一真正有价值的检查手段。
