他汀类药物是否会对糖尿病患者的糖化血红蛋白产生不利影响？
Do statins adversely affect the HbA of diabetic patients?
作者信息
Son W D, Teng C L
机构信息
BSc (Biomed), MBBS International Medical University (Clinical School Seremban) Malaysia. E-mail:
MMed (FamMed), FAFPM, FRACGP, AM International Medical University (Clinical School Seremban) Malaysia.
出版信息
Malays Fam Physician. 2017 Apr 30;12(1):39-40. eCollection 2017.
Abstract
This paper discusses the adverse effect of statins on the HbA levels of diabetic patients. Studies have shown that statins may slightly worsen the HbA level. The effects vary depending on the type of statins, the dosage and the duration of therapy. However, it has been confirmed that statin use has benefits that outweigh its harms. Therefore, a diabetic patient should be given advice on the need for appropriate lifestyle changes and the importance of continuing the statins.
摘要
本文讨论了他汀类药物对糖尿病患者糖化血红蛋白（HbA）水平的不良影响。研究表明，他汀类药物可能会使糖化血红蛋白水平略有恶化。其影响因他汀类药物的类型、剂量和治疗持续时间而异。然而，已证实使用他汀类药物的益处大于危害。因此，应向糖尿病患者提供有关适当改变生活方式的必要性以及继续服用他汀类药物的重要性的建议。
相似文献
1
Do statins adversely affect the HbA of diabetic patients?他汀类药物是否会对糖尿病患者的糖化血红蛋白产生不利影响？
Malays Fam Physician. 2017 Apr 30;12(1):39-40. eCollection 2017.
2
Statin therapy on glycemic control in type 2 diabetic patients: A network meta-analysis.他汀类药物治疗对2型糖尿病患者血糖控制的影响：一项网状Meta分析。
J Clin Pharm Ther. 2018 Aug;43(4):556-570. doi: 10.1111/jcpt.12690. Epub 2018 May 7.
3
Lower and higher-potency statins on glycemic control in type 2 diabetes: A retrospective cohort study.不同效力的他汀类药物对2型糖尿病患者血糖控制的影响：一项回顾性队列研究。
Diabetes Res Clin Pract. 2016 Oct;120:104-10. doi: 10.1016/j.diabres.2016.07.015. Epub 2016 Jul 30.
4
Statin-associated incident diabetes: a literature review.他汀类药物相关的新发糖尿病：文献综述
Consult Pharm. 2014;29(5):317-34. doi: 10.4140/TCP.n.2014.317.
5
Circulating monocyte chemotactic protein 1 (MCP-1), vascular cell adhesion molecule 1 (VCAM-1) and angiogenin in type 2 diabetic patients treated with statins in low doses.在低剂量他汀类药物治疗的 2 型糖尿病患者中循环单核细胞趋化蛋白 1（MCP-1）、血管细胞黏附分子 1（VCAM-1）和血管生成素。
Eur J Pharmacol. 2014 Oct 5;740:474-9. doi: 10.1016/j.ejphar.2014.06.041. Epub 2014 Jun 30.
6
Diabetogenic Action of Statins: Mechanisms.他汀类药物的致糖尿病作用：机制。
Curr Atheroscler Rep. 2019 Apr 30;21(6):23. doi: 10.1007/s11883-019-0780-z.
7
Statins and their increased risk of inducing diabetes.他汀类药物及其诱发糖尿病风险的增加。
Expert Opin Drug Saf. 2015;14(12):1835-44. doi: 10.1517/14740338.2015.1096343. Epub 2015 Oct 5.
8
Effects of background statin therapy on glycemic response and cardiovascular events following initiation of insulin therapy in type 2 diabetes: a large UK cohort study.背景他汀类药物治疗对 2 型糖尿病起始胰岛素治疗后血糖反应和心血管事件的影响：一项大型英国队列研究。
Cardiovasc Diabetol. 2017 Aug 22;16(1):107. doi: 10.1186/s12933-017-0587-6.
9
Diabetes Secondary to Treatment with Statins.他汀类药物治疗继发的糖尿病
Curr Diab Rep. 2017 Feb;17(2):10. doi: 10.1007/s11892-017-0837-8.
10
Effect of high-potency statins on HbA1c in patients with or without diabetes mellitus.强效他汀类药物对糖尿病患者及非糖尿病患者糖化血红蛋白（HbA1c）的影响。
J Pharm Health Care Sci. 2016 Mar 18;2:8. doi: 10.1186/s40780-016-0040-0. eCollection 2016.
本文引用的文献
1
Statins and glycaemic control in individuals with diabetes: a systematic review and meta-analysis.糖尿病患者使用他汀类药物与血糖控制：一项系统评价和荟萃分析
Diabetologia. 2014 Dec;57(12):2444-52. doi: 10.1007/s00125-014-3374-x. Epub 2014 Sep 23.
2
Differences between rosuvastatin and atorvastatin in lipid-lowering action and effect on glucose metabolism in Japanese hypercholesterolemic patients with concurrent diabetes. Lipid-lowering with highly potent statins in hyperlipidemia with type 2 diabetes patients (LISTEN) study –.瑞舒伐他汀与阿托伐他汀在日本合并糖尿病的高胆固醇血症患者中降脂作用及对糖代谢影响的差异。强效他汀类药物在2型糖尿病高脂血症患者中的降脂作用（LISTEN）研究。
Circ J. 2014;78(10):2512-5. doi: 10.1253/circj.cj-14-0810. Epub 2014 Sep 2.
3
Statin therapy on glycaemic control in type 2 diabetes: a meta-analysis.他汀类药物治疗 2 型糖尿病患者的血糖控制：荟萃分析。
Expert Opin Pharmacother. 2013 Aug;14(12):1575-84. doi: 10.1517/14656566.2013.810210. Epub 2013 Jul 5.
4
Statins for primary prevention of cardiovascular and cerebrovascular events in diabetic patients without established cardiovascular diseases: a meta-analysis.他汀类药物用于无心血管疾病的糖尿病患者心血管和脑血管事件的一级预防：一项荟萃分析。
Exp Clin Endocrinol Diabetes. 2012 Feb;120(2):116-20. doi: 10.1055/s-0031-1297968. Epub 2011 Dec 20.
5
Effects of rosuvastatin and atorvastatin on glycaemic control in Type 2 diabetes---the CORALL study.瑞舒伐他汀和阿托伐他汀对 2 型糖尿病患者血糖控制的影响---CORALL 研究。
Diabet Med. 2012 May;29(5):628-31. doi: 10.1111/j.1464-5491.2011.03553.x.
6
Statin therapy and risk of developing type 2 diabetes: a meta-analysis.他汀类药物治疗与2型糖尿病发生风险：一项荟萃分析。
Diabetes Care. 2009 Oct;32(10):1924-9. doi: 10.2337/dc09-0738.
Zotero 插件