Mokhtari Mozhgan, Basirkazeruni Hanieh, Rostami Mojtaba
Department of Pathology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pathology, Isfahan Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2017 Apr 17;6:45. doi: 10.4103/2277-9175.204588. eCollection 2017.
Hepatitis C infection is one of the health problems in the world. Several known risk factors are responsible in transmission of this infection. We are going to study the prevalence of these risk factors for different genotypes of hepatitis C and if possible, specify probable relations between each risk factor and transmission of each genotype.
This is a cross-sectional study done on 270 people who had positive anti-hepatitis C virus (HCV) antibody and HCV RNA. Demographic specificity and possible risk factors were collected using a questionnaire, and statistical analysis was done by SPSS software (version 20). Chi-square test used to estimate the prevalence and relation between each qualitative risk factor and HCV genotype transmitted. Analysis of variance was used for studying the prevalence and relation between quantitative risk factors and HCV genotypes.
The sample size was 270 persons. Of these, 217 (80.4%) were men and 185 (68.5%) were infected with genotype Type III. Most people were in age range of 31-40 years old 92 (34%). Single people were 126 (46.7%) and 169 (62.6%) were high school and university graduated. Tattooing as a risk factor had a meaningful relation with hepatitis C genotype ( < 0.001).
According to the findings, most people in central provinces of Iran with hepatitis C are carrying genotype III, with most prevalent risk factors such as intravenous drug use and unsafe sexual activity. Besides, tattooing had a significant association with hepatitis C genotype, so that in these groups of people, genotype I was more frequent isolated virus.
丙型肝炎感染是全球的健康问题之一。几种已知的危险因素导致了这种感染的传播。我们将研究这些危险因素在不同丙型肝炎基因型中的流行情况，并尽可能明确每个危险因素与每种基因型传播之间的可能关系。
这是一项对270名抗丙型肝炎病毒（HCV）抗体和HCV RNA呈阳性的人群进行的横断面研究。通过问卷收集人口统计学特征和可能的危险因素，并使用SPSS软件（版本20）进行统计分析。卡方检验用于估计每个定性危险因素与传播的HCV基因型之间的流行率和关系。方差分析用于研究定量危险因素与HCV基因型之间的流行率和关系。
样本量为270人。其中，217人（80.4%）为男性，185人（68.5%）感染了III型基因型。大多数人年龄在31 - 40岁之间，有92人（34%）。单身者有126人（46.7%），169人（62.6%）为高中和大学毕业。纹身作为一个危险因素与丙型肝炎基因型有显著关系（<0.001）。
根据研究结果，伊朗中部省份大多数丙型肝炎患者携带III型基因型，最常见的危险因素如静脉注射吸毒和不安全的性行为。此外，纹身与丙型肝炎基因型有显著关联，在这些人群中，I型基因型是更常见的分离病毒。
