Colvin Monica M, Smith Candice A, Tullius Stefan G, Goldstein Daniel R
Division of Cardiology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
J Clin Invest. 2017 Jun 30;127(7):2523-2529. doi: 10.1172/JCI90601. Epub 2017 May 15.
An increasing number of older people receive organ transplants for various end-stage conditions. Although organ transplantation is an effective therapy for older patients (i.e., older than 65 years of age), such as in end-stage renal disease, this therapy has not been optimized for older patients because of our lack of understanding of the effect of aging and the immune response to organ transplantation. Here, we provide an overview of the impact of aging on both the allograft and the recipient and its effect on the immune response to organ transplantation. We describe what has been determined to date, discuss existing gaps in our knowledge, and make suggestions on necessary future studies to optimize organ transplantation for older people.
越来越多的老年人因各种终末期疾病接受器官移植。尽管器官移植是老年患者（即65岁以上）的有效治疗方法，如在终末期肾病中，但由于我们对衰老的影响以及对器官移植的免疫反应缺乏了解，这种治疗方法尚未针对老年患者进行优化。在此，我们概述衰老对同种异体移植物和受者的影响及其对器官移植免疫反应的作用。我们描述了迄今为止已确定的内容，讨论了我们知识中存在的空白，并就未来必要的研究提出建议，以便为老年人优化器官移植。
