Prieto-Bermejo Rodrigo, Hernández-Hernández Angel
Department of Biochemistry and Molecular Biology, University of Salamanca, Salamanca 37007, Spain.
Antioxidants (Basel). 2017 May 13;6(2):32. doi: 10.3390/antiox6020032.
Eukaryotic cells have to cope with the constant generation of reactive oxygen species (ROS). Although the excessive production of ROS might be deleterious for cell biology, there is a plethora of evidence showing that moderate levels of ROS are important for the control of cell signaling and gene expression. The family of the nicotinamide adenine dinucleotide phosphate oxidases (NADPH oxidases or Nox) has evolved to produce ROS in response to different signals; therefore, they fulfil a central role in the control of redox signaling. The role of NADPH oxidases in vascular physiology has been a field of intense study over the last two decades. In this review we will briefly analyze how ROS can regulate signaling and gene expression. We will address the implication of NADPH oxidases and redox signaling in angiogenesis, and finally, the therapeutic possibilities derived from this knowledge will be discussed.
真核细胞必须应对活性氧（ROS）的持续产生。尽管ROS的过量产生可能对细胞生物学有害，但有大量证据表明适度水平的ROS对于细胞信号传导和基因表达的控制很重要。烟酰胺腺嘌呤二核苷酸磷酸氧化酶（NADPH氧化酶或Nox）家族已经进化到能够响应不同信号产生ROS；因此，它们在氧化还原信号传导的控制中发挥着核心作用。在过去二十年中，NADPH氧化酶在血管生理学中的作用一直是一个深入研究的领域。在这篇综述中，我们将简要分析ROS如何调节信号传导和基因表达。我们将探讨NADPH氧化酶和氧化还原信号传导在血管生成中的意义，最后，将讨论从这一知识中衍生出的治疗可能性。
