Nishizawa Toshinori, Yoshida Soichiro, Koga Fumitaka, Tanaka Hiroshi, Kaga Mihiro, Watanabe Kotaro, Fukushima Hiroshi, Nakanishi Yasukazu, Yokoyama Minato, Ishioka Junichiro, Matsuoka Yoh, Saito Kazutaka, Fujii Yasuhisa, Kihara Kazunori
Department of Urology, Tokyo Medical and Dental University Graduate School, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Department of Urology, Tokyo Medical and Dental University Graduate School, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Clin Imaging. 2017 Jul-Aug;44:121-126. doi: 10.1016/j.clinimag.2017.05.004. Epub 2017 May 5.
We investigated whether the standardized apparent diffusion coefficient (ADC) value reflects bladder cancer characteristics across different centers.
Ninety-eight bladder cancer patients underwent MRI at two institutions. Standardized tumor ADC (sT-ADC) was calculated by dividing absolute tumor ADC (aT-ADC) by that of gluteus maximus. We compared ADCs between MRI protocols according to grade and T-stage.
The differences in aT-ADC between MRI protocols were negated by sT-ADC. The best sT-ADC cut-offs to predict cancer aggressiveness in the development cohort worked in the validation cohort compared to the development cohort.
Standardized ADC overcomes the incompatibility between different MRI protocols.
我们研究了标准化表观扩散系数（ADC）值是否能反映不同中心的膀胱癌特征。
98例膀胱癌患者在两家机构接受了磁共振成像（MRI）检查。通过将肿瘤绝对ADC（aT-ADC）除以臀大肌的ADC来计算标准化肿瘤ADC（sT-ADC）。我们根据肿瘤分级和T分期比较了不同MRI检查方案之间的ADC值。
sT-ADC消除了不同MRI检查方案之间aT-ADC的差异。与开发队列相比，在验证队列中，开发队列中预测癌症侵袭性的最佳sT-ADC临界值有效。
标准化ADC克服了不同MRI检查方案之间的不兼容性。
