Steins Martin B, Eschbach Corinna, Villalobos Matthias, Thomas Michael
Pneumologie. 2017 May;71(5):297-306. doi: 10.1055/s-0043-102776. Epub 2017 May 15.
A consistent pain management together with treatment of dyspnoea belongs to the main issues in symptom control in particular in palliative thoracic oncology. Together with the medicamentous therapy the psychologic and social circumstances of the affected patients have to be considered as factors influencing the experience of pain. The therapeutic fundament according to the WHO guideline for cancer pain is the opiate based medicamentous adjustment combined with non-opioids. In principle, this should be performed preferably orally, as simply as possible, according to a fix drug schedule and individually adjusted to the needed dosage. Breakthrough pain has to be treated with rapidly efficacious, non-retarded analgetics. The typical adverse reaction profile for opiates like constipation and initial nausea should be considered prophylactically by applying concurrent medication with adjuvants. Co-analgesic drugs like anticonvulsiva or corticosteroids could support the analgetic effect and are used preferably in case of neuropathic pain. Primary aim in analgesic therapy is to achieve the best possible pain reduction and hence to safeguard quality of life.
持续的疼痛管理以及呼吸困难的治疗是姑息性胸部肿瘤学症状控制中的主要问题。除药物治疗外,还必须将受影响患者的心理和社会状况视为影响疼痛体验的因素。根据世界卫生组织癌症疼痛指南,治疗基础是基于阿片类药物的药物调整并结合非阿片类药物。原则上,这最好通过口服进行,尽可能简单,按照固定的用药时间表,并根据所需剂量进行个体化调整。爆发性疼痛必须用起效迅速、非缓释的镇痛药治疗。对于阿片类药物典型的不良反应,如便秘和初始恶心,应通过同时使用辅助药物进行预防性处理。抗惊厥药或皮质类固醇等辅助镇痛药可增强镇痛效果,优选用于神经性疼痛的情况。镇痛治疗的主要目标是尽可能减轻疼痛,从而保障生活质量。