Seier Mara, Hiller Amie
Northwest Parkinson Disease Research Education and Clinical Center, Portland VA Medical Center, Portland, OR, USA; Department of Neurology, Oregon Health Sciences University, Portland, OR, USA.
Northwest Parkinson Disease Research Education and Clinical Center, Portland VA Medical Center, Portland, OR, USA; Department of Neurology, Oregon Health Sciences University, Portland, OR, USA.
Parkinsonism Relat Disord. 2017 Jul;40:11-17. doi: 10.1016/j.parkreldis.2017.05.007. Epub 2017 May 11.
Pregnancy does not often occur in the setting of Parkinson's disease (PD) as the most common age of onset is beyond the childbearing years, yet management of these two conditions is crucial for the health of both mother and child. Here we review treatment data of PD during pregnancy, primarily from case reports and drug registries, and focus on available evidence regarding the pregnancy risks for patient and fetus. Historically, it was reported that many women had worsening of symptoms during pregnancy but this may be because anti-parkinsonian medications were not recommended or were under dosed. Levodopa has the best safety data for use in pregnancy and amantadine should be avoided in women who are pregnant or trying to become pregnant. The data for other pharmacological and surgical treatments is less clear. There is no evidence that women with PD have higher rates of birth or fetal complications.
帕金森病（PD）患者通常不会怀孕，因为其最常见的发病年龄超出了育龄期，但这两种情况的管理对母婴健康都至关重要。在此，我们回顾了孕期帕金森病的治疗数据，主要来自病例报告和药物登记处，并关注有关患者和胎儿妊娠风险的现有证据。从历史上看，有报道称许多女性在怀孕期间症状会加重，但这可能是因为不建议使用抗帕金森药物或用药剂量不足。左旋多巴在孕期使用的安全性数据最佳，孕妇或试图怀孕的女性应避免使用金刚烷胺。其他药物和手术治疗的数据则不太明确。没有证据表明帕金森病女性的分娩或胎儿并发症发生率更高。
